Ukujiya kuyinkomba yokumelana koketshezi nokugeleza, esinye sezici ezithonya ikhwalithi yomkhiqizo, ukusebenza kahle kwenqubo kanye nokuhambisana nemithetho.ukulawula i-viscosity ye-nlineiguqula ukukhiqizwa kwemithi ngokunika amandla ukuqapha kanye nokulungisa ngesikhathi sangempela, isuse ukubambezeleka kanye nokungahambisani kwezindlela zendabuko ezisekelwe elabhorethri.
Ukuqina Kwenqubo Embonini Yezemithi
Ukuchama okusenquboniKubhekisele ekulinganisweni kwesikhathi sangempela kanye nokulawulwa kokumelana nokugeleza koketshezi ngesikhathi sokukhiqizwa kwemithi. Ukuhlolwa kwe-viscosity okusekelwe elabhorethri kwendabuko, okubandakanya ukusampula njalo kanye nokuhlaziywa okungaxhunyiwe ku-inthanethi; ukuqapha i-viscosity enqubweni kunikeza idatha eqhubekayo ngqo kusuka emgqeni wokukhiqiza.
Kubalulekile ku consi-istenti-visci-ositu-yukulungiswakuizinqubo zokukhiqiza eziqhubekayo zemithi ngama-suspension, ama-gel, kanye nama-emulsion, njll. Isibonelo, i-viscosity yesisombululo se-monoclonal antibody inganquma ukuthi ingafakwa kanjani, kuyilapho i-viscosity ye-gel yangaphandle ithinta ukusabalala kwayo kanye nokwamukelwa kwesiguli.
Ukulawulwa kwe-viscosity ngesikhathi sangempela kuqinisekisa ukuthi ukuphambuka kubanjwa ngokushesha, okuvumela ukulungiswa kwemingcele yokwakheka noma yenqubo ukuze kugcinwe ukuhambisana nezindinganiso eziqinile zomthetho. Ngokufaka ukuqapha kwe-viscosity emgudwini wokukhiqiza, abakhiqizi bangafinyelela ukuhlanganiswa okungenamthungo neukukhiqizwa okuqhubekayo kwemithi, okuthuthukisa kokubili ukukhiqiza kanye nokuthembeka komkhiqizo.
Izici Ezithonya Ukulinganiswa Kokugoba
Ukulinganisa okunembile kwe-viscosity kubalulekile kodwa kungathonywa yizici eziningana, ngasinye sidinga ukucatshangelwa ngokucophelela ukuqinisekisa idatha ethembekile kuukukhiqiza imithi okuqhubekayo:
●Izinga lokushisa: Ukuqina komzimba kuzwela kakhulu ekushintsheni kwezinga lokushisa. Ukwehla okungu-1°C nje kungandisa ukuqina komzimba ngamaphesenti afinyelela ku-10, njengoba uketshezi luba namandla okumelana nokugeleza emazingeni okushisa aphansi. Ukulawula izinga lokushisa okunembile, ngokuvamile ngaphakathi kuka-0.02°C, kubalulekile ekulinganisweni okulinganayo.
●Izinga Lokugunda: Uketshezi olungeyona i-Newtonian, oluvame kakhulu kwezokwelapha, lubonisa izinguquko ze-viscosity ngaphansi kwamazinga ahlukahlukene okucheba. Uketshezi olunciphisa ukucheba njengejeli luyancipha ekuqineni kwe-viscosity ngaphansi kokucheba okuphezulu, kuyilapho uketshezi olukhulisa ukucheba lukhula.
●Ukwakheka Nokugxila: Ukuhlushwa okuphezulu kwezithako ezisebenzayo zemithi (ama-API) noma izinto ezisizayo kungakhuphula kakhulu i-viscosity, ikakhulukazi kuma-biologics afana nama-antibody e-monoclonal angaphezu kuka-100 mg/mL.
●Ingcindezi: Nakuba kungeyona into ethinta kakhulu izinga lokushisa, ingcindezi ingathinta i-viscosity, ikakhulukazi ezinhlelweni zokucindezela okuphezulu njengamaphampu noma ama-extruder, lapho ingcindezi ekhulayo inciphisa ukuhamba kwama-molecule, okuphakamisa i-viscosity.
●Ukulingana KwesampulaAmasampula angalingani, njengokumiswa okune-sedimentation noma amabhamuza omoya, angasonta izilinganiso, okudinga ukuxuba noma ukukhipha igesi ngendlela efanele ngaphambi kokuhlaziywa.
Umthelela Wokunamathelana Ezinqubweni Zokukhiqiza
Ukuqina kuthonya ukusebenza kahle kanye nekhwalithiukukhiqizwa okuqhubekayo kwemithingezigaba eziningi:
●Ukuxuba: Ukuqina kulawula ukufana nokusebenza kahle kokuxuba ama-API nezinto ezisizayo. Uketshezi olunamandla okuvama ludinga abaxubi abaqinile (isb., ama-anchor agitators) ukuvimbela ukuhlukaniswa kwesigaba, kuyilapho uketshezi olunamandla okuvama kungaholela ekuxubeni ngokweqile nasekungeneni komoya.
●Ukugcwalisa: Ukugcwaliswa okunembile kwama-vial, ama-syringe, noma ama-capsule kuncike ekuqineni. Uketshezi olunamandla amakhulu lungabangela ukuvaleka noma ukungalingani komthamo, okuthinta ukunemba, kuyilapho uketshezi olunamandla amancane lungabangela ukuchaphazeka noma ukuvuza.
●Ukupakisha: Ukuqina kuthinta ukuzinza kanye nobuqotho bemikhiqizo epakishiwe. Isibonelo, amafomula aqine kakhulu angase angagelezi kahle ezitsheni, kuyilapho imikhiqizo eqine kakhulu ibeka engcupheni yokuvuza noma yokungazinzi ngesikhathi sokugcina.
●Ukupompa Nokugeleza: Ukuqina kunquma ukumpompa kanye nokuziphatha kokugeleza ngamapayipi. Uketshezi olunamandla okuqina lukhulisa ukwehla kwengcindezi, okudinga amandla okufaka aphezulu, kuyilapho uketshezi olunamandla okuqina lungabangela ukugeleza okuphazamisayo, okuthinta ukulawulwa kwenqubo.
●Ukusebenza Kohlelo Lokusebenza: Ngemijovo, ukujiya kuthinta ukukwazi ukufaka inaliti kanye nenduduzo yesiguli, kuyilapho ngemijovo yomlomo, kuthinta ukunambitheka kanye nezakhiwo zokugcoba umphimbo.
Umongo Womlando Nokuvela Kokulinganisa Ukuqina
Ukulinganiswa kwe-viscosity kuthuthuke kakhulu, kuqhutshwa isidingo sokunemba kuizinqubo zokukhiqiza eziqhubekayo zemithiEkuqaleni kwekhulu lama-20, i-viscosity yayilinganiswa ngesandla kusetshenziswa amathuluzi alula njengezinkomishi zokugeleza kanye nama-viscometer engilazi e-capillary, ayethembele ekugelezeni okuqhutshwa amandla adonsela phansi.
Lezi zindlela, nakuba zisebenza kahle kuma-Newtonian fluids, zazidinga umsebenzi omningi futhi azifanele ukuqapha ngesikhathi sangempela. Ukwethulwa kwama-viscometer ajikelezayo maphakathi nekhulu lama-20 kwaphawula inqubekela phambili, okuvumela ukulinganiswa kwe-viscometer okuguquguqukayo kwama-non-Newtonian fluids. Ukufika kokuzenzakalelayo ngasekupheleni kwekhulu lama-20 kwaletha "ama-algorithms okwelapha" okulandelela izinguquko ze-viscometer ngesikhathi sokusabela.
Izinselele Zenqubo Zokulawulwa Kokunamathela Okuqondile Ekukhiqizeni Imithi
Ukuqalisaukulawula ukuthambekela okuqondilekuukukhiqiza imithi okuqhubekayoinikeza izinselele eziningana:
●Ukuxhumana Nedatha Yelebhu: Ukuvumelanisa izilinganiso eziqondile nemiphumela esekelwe elebhu kuyinkimbinkimbi ngenxa yokwehluka kwamazinga okusika, izinga lokushisa, kanye nemishini. Ukulinganisa okufanele kanye nokulinganisa kubalulekile.
●Ukuziphatha Okungeyona EyaseNewtonian: Uketshezi oluningi lwemithi, njengamajeli kanye nama-suspension, lubonisa ukuziphatha okungeyona i-Newtonian, okudinga ama-viscometer akwazi ukubhekana namazinga okugunda aguquguqukayo.
●Izimo Zenqubo Enzima: Amazinga okushisa aphezulu, ukucindezela, noma uketshezi oluqothulayo kungalimaza izinzwa, kudingeke imiklamo eqinile njengokwakhiwa kwensimbi engagqwali engu-316L.
●Isampula Yokungafani: Ukuthuthwa kwendle, ukufakwa komoya, noma ukuhlukaniswa kwesigaba kuma-suspension kungaphazamisa ukufundwa, kudinga ukuhlanganiswa kwangaphambili kokulinganisa.
●Ukugcinwa Nokuhlanza: Ama-viscometer angaphakathi kumele kube lula ukuwahlanza nokunakekela ukuze ahlangabezane nezindinganiso zokuhlanzeka kwemithi eziqinile, njengalezo ezidinga ukuxhumeka kwe-aseptic.
●Izindleko Nokuhlanganiswa: Ukutshalwa kwezimali kokuqala okuphezulu kanye nokuhlanganiswa kwemigqa yenqubo ekhona kungaba yizithiyo, ikakhulukazi kubakhiqizi abancane.
Amasu Okulinganisa Amanje Okuqina
Amasu okulinganisa i-viscosity yesimanje ahlangabezana nezidingo zeukukhiqizwa okuqhubekayo kwemithi:
●I-Capillary Viscometry: Ilinganisa i-kinematic viscosity ngokubeka isikhathi sokugeleza koketshezi ngepayipi elilinganisiwe. Ilungele uketshezi lwe-Newtonian njengezixazululo ezincibilikisiwe kodwa ayifaneleki kangako uketshezi olunamandla aphezulu noma olungewona uketshezi lwe-Newtonian.
●I-Rotational Viscometry: Isebenzisa i-spindle ejikelezayo ukukala i-viscosity enamandla, efanelekile kokubili uketshezi lwe-Newtonian nolwe-non-Newtonian.
●I-Vibrational Viscometry: Isebenzisa izinzwa ezinyakazayo ukukala ubungqingili ngesikhathi sangempela, okulungele ukusetshenziswa okuqondile ngenxa yokulula kokufakwa nokuhlanza.
●I-Microfluidic Viscometry: Isebenzisa ama-chip e-microfluidic kumasampula anomthamo ophansi (<500 µL), okunikeza ukunemba okuphezulu kwe-biologics kanye nama-gel.
●I-Viscometry Yokucindezela Okuhlukile: Ilinganisa i-viscosity ngokwehla kwengcindezi ku-capillary, ngokusekelwe emthethweni kaPoiseuille, osebenza kahle ekulawuleni inqubo eqondile.
| Ubuchwepheshe | Okufanelekile Kakhulu | Izinzuzo | Ukulinganiselwa |
| I-Capillary | Uketshezi lwe-Newton | Ukunemba okuphezulu | Kunqunyelwe kuketshezi olune-viscosity ephansi |
| Ukujikeleza | Uketshezi olungeyona i-Newtonian | Kuguquguqukayo, kujwayelekile | Kudinga amasampula amaningi |
| Ukudlidliza | Ukuqapha okusemgqeni | Kulula ukuyihlanza, ngesikhathi sangempela | Ububanzi besilinganiso sokucheba obulinganiselwe |
| I-Microfluidic | I-Biologics, amavolumu aphansi | Ukunemba okuphezulu, amasampula amancane | Akufanele uketshezi oluqinile kakhulu |
Ithebula 1: Ukuqhathaniswa kwamasu okulinganisa i-viscosity ekusetshenzisweni kwemithi.
Ama-Viscometer e-Pharma aku-inthanethi e-Lonnmeter
Ama-viscometer aku-inthanethi eLonnmeter aklanyelweukukhiqizwa okuqhubekayo kwemithi, enikeza izixazululo eziqinile zokulawula i-viscosity ngesikhathi sangempela. Lawa madivayisi, akhiwe ngensimbi engagqwali engu-316L, ahlanganiswa kalula emigqeni yenqubo enokuxhumeka kwe-aseptic. Izici ezibalulekile zifaka:
● Ububanzi Bokugoba Okubanzi: Iyakwazi ukuqapha uketshezi olune-viscosity ephansi kuya kwephezulu, kusukela ezixazululweni ezincibilikisiwe kuya kuma-gel.
● Ukuqapha Kwangempela: Ihlinzeka ngedatha ye-viscosity kanye nezinga lokushisa njalo ngomzuzwana, ingathinteki ukushintshashintsha kwesilinganiso sokugeleza.
● Ukulungiswa Okuphansi: Idizayini eqinile engenazo izinto ezidliwayo, iqinisekisa ukuhlanzwa okulula nokuhambisana nezindinganiso zokuhlanzeka kwemithi.
●Ukuhlanganiswa Okuzenzakalelayo: Isekela ukulungiswa kokulinganisa okuzenzakalelayo kanye nokuxuba, okuthuthukisa ukusebenza kahle kwenqubo.
Izinzuzo Zokuhlanganisa Ama-Viscometer E-Pharma Aku-inthanethi Emigqeni Yenqubo
Ukuhlanganisaku-inthanethiphai-rma ama-viscometernjengoba iLonnmeter ingenaukukhiqizwa okuqhubekayo kwemithiiveza izinzuzo ezibalulekile:
●Ikhwalithi Yomkhiqizo Ethuthukisiwe: Ukulawulwa kwe-viscosity yesikhathi sangempela kuqinisekisa ukwakheka okuhambisanayo, kunciphisa ukwenqatshwa kwe-batch ngamaphesenti afinyelela ku-20%.
● Ukusebenza Kahle Okukhuphukile: Ukuqapha okuqhubekayo kuqeda isidingo sokuhlolwa kwelebhu njalo, ukunciphisa isikhathi sokungasebenzi kanye nezindleko zabasebenzi.
● Ukonga Izindleko: Ukuthamba okulungiselelwe kunciphisa ukusetshenziswa kwezinto ezilahliwe kanye namandla, okuthuthukisa izinzuzo.
● Ukuthobela Imithetho: Idatha eqondile ye-viscosity iqinisekisa ukunamathela ezindinganisweni eziqinile, okwenza kube lula ukuhlolwa nokulandelela.
● Ukuphepha Okuthuthukisiwe: Ukuzenzakalela kunciphisa ukuchayeka komqhubi kuketshezi oluyingozi, kuthuthukisa ukuphepha emsebenzini.
●Ukuthuthukisa Inqubo: Idatha yesikhathi sangempela ivumela ukulungiswa okusebenzayo, okuqinisekisa ukusebenza okulinganayo phakathi kokuxuba, ukugcwalisa, kanye nokupakisha.
Phakamisa eyakhoizinqubo zokukhiqiza eziqhubekayo zemithingokulawula i-viscosity okusemgceni okuphambili. Ama-viscometer aku-inthanethi e-Lonnmeter aletha ukunemba, ukuthembeka, kanye nokusebenza kahle, okuqinisekisa ukuthi imikhiqizo yakho ihlangabezana nezindinganiso zekhwalithi ephezulu. Ungavumeli izinselele ze-viscosity zibe sengozini ekukhiqizweni kwakho. Xhumana nathi manje ukuze uthole isilinganiso esenzelwe wena bese uthola ukuthi izixazululo zethu zingayiguqula kanjani indlela yakho.ukukhiqizwa okuqhubekayo kwemithiCela i-RFQ yakho namuhla bese uthatha isinyathelo sokuqala sokukhiqiza okungenazihibe, okuhambisanayo, futhi ongabizi kakhulu.
Isikhathi sokuthunyelwe: Agasti-25-2025
