Ukubeka iliso kwiStarch Concentration kwiWet Granulation
Isitatshi sisixhobo esibalulekileyo ekuvelisweni kweepilisi ngenxa yokuguquguquka kwazo kunye nokusebenza kakuhle kweendleko. Imingeni kwinkqubo yokuxubana okumanzi igxile kulawulo oluchanekileyo loxinzelelo lwayo kunye nomxholo wokufuma. Olu tshintsho lubangela eziphambili zeziphene zomgangatho wemveliso, njengokuqhekeka kweepilisi, ukutshintsha kobunzima, kunye nokunyibilika okungaguqukiyo.
I-Process Analytical Technology (PAT), ingakumbi iimitha zoxinzelelo lwe-ultrasonic, zokujonga ngexesha langempela, ezikwi-line zilawula uxinano lwe-starch binder, zenza utshintsho kwi-paradigm yendabuko, esebenzayo, esekelwe kuvavanyo ukuya kwi-proactive, esekelwe kulawulo.
Imingeni yokujonga i-Urea kwi-Intanethi
Iindima eziPhambili zeStarch kwiifom zeDosage eziQinileyo
Isitatshi njengesixhobo esisebenzayo
Isitatshi yi-biopolymer yendalo, engenabungozi, kwaye inoqoqosho, yenye yezona zinto zisetyenziswa kakhulu kwiifom zedosi eqinileyo ezifana neepilisi. Ukuguquguquka kwayo yinzuzo ephambili, evumela ukuba isebenze imisebenzi emininzi ngaphakathi kwefomyula efanayo, ihlala isebenza njenge-binder kunye ne-disintegrant kwi-granulation emanzi.
Iimpawu zokusebenza kwesitatshivarykwimithombo yayo yezityalo, efana nombona, iitapile, okanye i-sorghum, nto leyo echaza umlinganiselo wayo we-amylose-to-amylopectin kunye nemo ye-granular. Olu mahluko luthetha ukuba iistatshi ezivela kwimithombo eyahlukeneyo azinakutshintshwa. Umzekelo, istatshi seetapile sihlala sine-viscosity ephezulu, ngelixa istatshi seembona sineempawu zaso ezithile zokuncamathisela. Ukuqonda ezi mpawu zemithombo ethile kubalulekile ekuphuhlisweni kwefomyula.
Le theyibhile ilandelayo ishwankathela ubudlelwane phakathi kwemithombo eyahlukeneyo yesitatshi kunye nemisebenzi yayo yokusebenza:
| Umthombo wesitatshi | Umlinganiselo oqhelekileyo we-Amylose/Amylopectin | Iimpawu Eziphambili Zokusebenza | Iimpawu zefiziksi-zekhemikhali |
| Umbona | Malunga ne-27:73 | Isibopheleli, isiqhekeza, isizalisi | Ubushushu beGelatinization, i-viscosity ephakathi |
| Amazambane | Malunga ne-22:25 | I-Disintegrant, i-filler | Ubushushu obuphantsi be-gelatinization, i-viscosity ephezulu |
| Ingqolowa | Malunga ne-19.2:80.8 | Isibopheleli, ukungathobeli | Ukuqhekeka okukhawulezayo, amazinga aphezulu okuqhekeka |
Ngaba unemibuzo malunga nokwenza ngcono iinkqubo zemveliso?
Inkcazo yeNkqubo yeSitashi
Isitatshi njengeBinder: Ukubaluleka kweGelatinization
Isitatshi sisebenza njengesihlanganisi esisebenzayo kwi-granulation emanzi ngenxa ye-gelatinization, inkqubo apho ubushushu namanzi kuphazamisa ngokungenakuphikiswa isakhiwo sayo sekristale. Isitatshi sendalo, esinganyibiliki emanzini abandayo, sifuna eli nyathelo lokupheka ukuze simanzise ii-polymers zayo ze-amylose kunye ne-amylopectin, nto leyo evumela amandla azo okubopha.
Ulwakhiwo lwe-Amylopectin olunamasebe amaninzi, olufana nomthi lubonelela ngeendawo ezininzi zokuncamathisela, nto leyo eyivumela ukuba ibambe amasuntswana kunye ngempumelelo. Okwangoku, i-amylose, kunye nolwakhiwo lwayo oluthe tye, yonyusa i-viscosity kwaye yenza inethiwekhi yejeli njengoko iphola, iqinisa uzinzo lwe-granule.
Ukuze kulungiswe iinkqubo zoshishino kwaye kupheliswe isidingo sokupheka, kwaveliswa iistatshi ezifakwe igelatin. Ezi statshi, ezifakwe igelatin ngokupheleleyo okanye inxalenye yazo, ziyanyibilika emanzini abandayo kwaye zingongezwa njengomgubo owomileyo kwiifomyula. Ngexesha lokuxuba, amanzi ayazivuselela kwindawo yazo, okwenza kube lula ukuvelisa ngelixa eqinisekisa ukusebenza okuqinileyo kokubopha.
Isitatshi njengeSithintelo: Ukudumba kunye nokugqwala
Isitatshi siyinto eqhelekileyo eqhekekileyo, kwaye indlela yaso yokusebenza ikukudumba. Xa ithebhulethi idibana nesixhobo samanzi, amanzi angena kwi-matrix yethebhulethi enemingxuma ngokusebenzisa isenzo se-capillary (wicking). Iigranules zesitatshi ziyafunxa amanzi aze avuvuke ukuya kuthi ga kubuninzi bawo bokuqala. Uxinzelelo lwangaphakathi oluveliswa koku kudumba lwanele ukoyisa amandla okubopha ethebhulethi kwaye lubangele ukuba iqhekeke ibe ziingceba ezincinci.
Ukusebenza kakuhle kwesitatshi njengento eqhekekayo kuphenjelelwa zizinto ezifana noxinzelelo lwayo, ubungakanani besuntswana, kunye namandla okucinezelwa asetyenziswayo. Isiphumo esiphambili kukuba nangona ukudumba kuyindlela elawulayo, ezinye izinto, ezifana nokugxothwa kwamasuntswana kunye nokuphazamiseka nje kweebhondi zehydrogen, nazo zinegalelo ekuqhekekeni.
Imingeni kwi-Wet Granulation of Tabmasivumele
Uxinzelelo lwesitatshi kunye nobuninzi bokufuma
Ukuguquguquka koxinzelelo lwe-starch paste okanye ukufuma komxube we-powder blend "ziingongoma ezibuhlungu" eziphambili kwi-granulation emanzi. Ukusebenza kwe-starch njenge-binder kuxhomekeke kakhulu ekulungisweni kwayo. Umzekelo, ukuba i-starch paste "ayiphekwanga kakuhle," ayizukusebenza njenge-polymer ebophayo esebenzayo kuba isakhiwo sayo se-crystalline asiguquki.
Indima yokufuma iyinkimbinkimbi. Kumanqanaba aphantsi, amanzi anokusebenza njengesithambisi, nto leyo ephucula ukuhamba kwamanzi. Nangona kunjalo, xa umxholo wokufuma udlula kwinqanaba elibalulekileyo, kwandisa kakhulu ukuhlangana kwamasuntswana ngokwenza iibhulorho ezinamandla zolwelo, nto leyo enciphisa ukuhamba kwamanzi. Oku kunokukhokelela ekuzalisweni okungonelanga nokungahambelaniyo ngexesha lokuxinwa kwethebhulethi, nto leyo ebangela ukutshintsha kobunzima bethebhulethi.
Olu lwalamano ludala isiphumo se-domino. Ukungakwazi ukuhamba kakuhle ngenxa yokuguquguquka komswakama akuchaphazeli nje kuphela ubunzima obufanayo kodwa kukwachaphazela ukuhambelana kwamandla okucinezelwa, okukhokelela ekusasazweni ngokubanzi kobunzima bethebhulethi kunye noxinano, kwaye ekugqibeleni kuchaphazela ukusebenza kokunyibilika. Oku kugxininisa unxibelelwano oluntsonkothileyo phakathi kweempawu zomgangatho ezibonakala zingahambelani.
Amanqaku eNtlungu yeNkqubo
Uxinzelelo olungalunganga lwe-binder okanye ukusebenza okunganelanga kwe-starch polymer kunokukhokelela kwiigranules ezibuthathaka kwaye, ngenxa yoko, iipilisi "ezithambileyo" ezinokuthi ziqhekeke kwaye ziqhekeke. Ngokwahlukileyo koko, uxinzelelo oluphezulu kakhulu lwe-binder okanye iigranulation ezigqithisileyo zinokubangela iigranules ezixineneyo neziqinileyo, ezinokukhokelela kwiziphene ezifana nokuqhekeka kunye ne-lamination ngexesha lokuxinwa kwethebhulethi ngenxa yokubanjwa komoya kunye nokuguquguquka kweplastiki okwaneleyo.
Inkqubo yokuxubana okumanzi inovelwano kakhulu kwizinto ezifana nexesha lokuxubana okumanzi kunye nesantya se-impeller, nto leyo enokubangela ukuba i-granulation ibe ngaphezulu kwe-granule kunye nokwanda koxinano lwe-granule. Lo ngumceli mngeni obalulekileyo.
Into ephawulekayo kukunxibelelana okungaqhelekanga phakathi kwamandla e-granule kunye namandla okutsalwa kwethebhulethi. Ingqiqo eqhelekileyo kukuba ii-granule ezinamandla, ezixineneyo—eziveliswe, umzekelo, yi-granulation ephezulu—zifanele zivelise iipilisi ezinamandla. Nangona kunjalo, ubungqina bubonisa ukuba ii-granule eziveliswe yi-granulation ephezulu, ngelixa zixineneyo kwaye zinamandla, ziphumela kwiipilisi ezinamandla okutsalwa aphantsi. Oku akungqubani nje. Kubonisa ukuba nangona i-intra-granule bonding inokuba namandla, ii-inter-granule bonds ezenziwe ngexesha lokuxinwa kwethebhulethi zibuthathaka. Oku kungenxa yokuba ii-granule ezixineneyo aziplastiki kangako kwaye aziguquguquki kangako phantsi kokuxinwa. Oku kunciphisa ukuguquguquka kunciphisa indawo yoqhagamshelwano phakathi kwee-granule kwaye kuthintele ukwakheka kwee-bridges eziqinileyo, okubangela ukuba ithebhulethi yokugqibela ibe buthathaka ngoomatshini nangona ii-granule zona zinamandla. Ke ngoko, ukulawula i-granulation endpoint akubhekiselele ekukhuliseni amandla okanye uxinano lwe-granule, kodwa malunga nokufikelela kwibhalansi efanelekileyo eqinisekisa ukuhamba kakuhle kunye nokucinezeleka okwaneleyo ukuvelisa ithebhulethi yokugqibela eqinileyo.
Impembelelo yokuxinana kwesitatshi kwiimpawu zokugqibela zoMgangatho weMveliso
Ubunzima kunye nokungaguquguquki
Ukwanda koxinzelelo lwe-binder kudla ngokuphumela ekubeni iipilisi zibe nobunzima obuphezulu kunye nokungaguquguquki okuphantsi. Isitatshi sibonelela ngeempawu zokubopha eziphakathi xa kuthelekiswa neepolymers zokwenziwa ezifana ne-PVP, ezihlala zivelisa iipilisi ezithambileyo kodwa ezineempawu zokuqhekeka ezingcono. Olunye uphando olwenziwe kwisitatshi sombona esisandula ukugawulwa lufumanise ukuba uxinzelelo lwe-binder oluyi-3% ukuya kwi-9% yayiluluhlu olufanelekileyo lokufikelela kwiimpawu zomzimba ezamkelekileyo.
Ukuqhekeka kunye nokuQhawulwa
Kukho ulwalamano olucacileyo oluchaseneyo phakathi koxinzelelo lwe-starch binder kunye nesantya sokunyibilika kwesiyobisi. Njengoko uxinzelelo lwe-binder lusanda, iipilisi ziba nzima kwaye ixesha lokuqhekeka kwazo liyakhula, nto leyo ebangela ukuba kuncitshiswe ukukhutshwa kwesithako esisebenzayo seyeza (API).
Esi siphumo sokulibazisa sesitatshi ekunyibilikeni sinokuchazwa ngoomatshini ngokwenziwa "komaleko ovuzayo". Xa ithebhulethi equlethe istatshi ivezwe kwindawo yokunyibilikisa, istatshi kumphezulu wethebhulethi siyadumba kwaye senze umaleko oqinileyo, ofana nejeli. Olu maleko wejeli alunazo kakhulu i-API. Ngenxa yoko, i-API yokunyibilikisa kwisiseko sethebhulethi kufuneka isasazeke kule matrix yesitatshi esiqinileyo nesivuvukileyo ukuze ifikelele kwindawo yokunyibilikisa i-bulk. Le nkqubo yokusasazeka linyathelo elicothayo, elinciphisa izinga.
Ubukhulu kunye nobukhulu bolu layer luphumayo buhambelana ngokuthe ngqo noxinzelelo lwesitatshi kunye nomlinganiselo walo we-gelatinization. Ke ngoko, iipropati zesitatshi ezingahambelaniyo okanye uxinzelelo zikhokelela ngokuthe ngqo kwiiprofayili zokunyibilika eziguquguqukayo, oluphawu lomgangatho obalulekileyo (CQA) oluchaphazela ukufumaneka kwamayeza.
Uxinano lweGranule kunye neTablet
Iimpawu eziphambili zokuvavanya umgangatho we-granule ziquka uxinano olukhulu, uxinano olucociweyo, kunye neCompressibility Index (CI). Izifundo zibonise ukuba amaxesha amade obunzima obumanzi okanye isantya esiphezulu se-impeller sonyusa uxinano olukhulu lwee-granule ngenxa yokuhlanganiswa okucacileyo.
Olu xinano, nangona luphucula ukuhamba kwamanzi, lubangela ukuba iCompressibility Index ibe sezantsi, nto leyo ethetha ukuba iigranules kunzima ukuzicinezela. Ngenxa yoko, ithebhulethi yokugqibela inokuba buthathaka kunokuba bekulindelwe okanye ifune amandla aphezulu okuxinzelela, nto leyo enokubangela ukuba izixhobo ziguge okanye iingxaki ezifana nokuqhekeka kwethebhulethi. Oku kudala i-feedback loop enzima apho utshintsho lwenkqubo encinci, njengokunyuka okuncinci koxinzelelo lwesitatshi, lunokuba nefuthe elibalulekileyo nelingaqinisekanga kumgangatho wemveliso yokugqibela.
| Uxinaniso lweStarch Binder (% w/w) | Ukuqina kwethebhulethi (N) | Ukuthamba kweTablethi (%) | Ixesha (ama) lokuqhekeka |
| 0% | Akukho Mbophi | N / A | N / A |
| 3% | 20 – 30 | <1% | Ayixhomekekanga kumandla okucinezelwa |
| 6% | 20 – 30 | <1% | Ayixhomekekanga kumandla okucinezelwa |
| 9% | 20 – 30 | <1% | Ayixhomekekanga kumandla okucinezelwa |
| 15% | 20 – 30 | <1% | Iyanda ngamandla oxinzelelo |
Qaphela: Amaxabiso obunzima asekelwe kwidatha yamandla athile okucinezelwa.
Ukubaluleka kokubeka esweni ngexesha langempela
Imida yoLawulo loMgangatho weMveli
Iindlela zemveli zokulawula umgangatho, ezinje ngohlalutyo lwe-intanethi okanye lwe-intanethi lwee-granules okanye iipilisi ezomisiweyo, ziyasebenza ngokwemvelo. Zixhomekeke ekuthatheni iisampulu novavanyo oluthatha ixesha elide, zinganiki ngxelo ngexesha langempela kwinkqubo eqhubekayo. Olu tshintsho lwexesha lwenza kube nzima ukuthintela ukuveliswa kweebhetshi ezingahambelaniyo, nto leyo ekhokelela kwinkunkuma enkulu yezinto kunye nelahleko yemali.
Isisombululo sokuJonga ukuXinzelelwa kweStarch
Iimitha zoxinzelelo ze-Ultrasonicmisela uxinzelelo okanye uxinano lolwelo ngokulinganisa isantya apho igagasi lesandi lidlula khona kulo. Isantya sesandi ngumsebenzi othe ngqo weempawu zomzimba zolwelo, kubandakanya uxinzelelo kunye nobushushu balo.
Le teknoloji ifanelekile kwiinkqubo zamayeza ngenxa yeenzuzo zayo:
- Ayihlaseli:Isensor ayinazo iindawo ezihambayo kwaye ingafakwa kumbhobho okanye kwisitya, inika imilinganiselo yexesha langempela ngaphandle kokuphazamisa ukuhamba kwenkqubo.
- Ukungakhethi cala:Umlinganiselo awuchaphazeleki ngumbala, ukucaca, okanye isantya sokuhamba kolwelo, eziziingxaki eziqhelekileyo kwiindlela zokukhanya.
- Ngokuthe ngqo nangoomatshini:Ilinganisa ngokuthe ngqo uxinaniso lwe-starch paste, iparameter yenkqubo ephambili enxulunyaniswa nomgangatho wemveliso yokugqibela.
Indawo yoFakelo lweMeter yoXinzelelo lweUltrasonic kwi-Intanethi
Olu fakelo lugxile ekulungiseleleni i-binder kunye nesigaba sokongeza, esenzeka kwangoko emva kokuxuba umgubo owomileyo kodwa ngaphambi kokuxutywa ngamanzi. Olu lungiselelo luvumela ukulungiswa kwangaphambili koxinzelelo lwe-starch paste kunye ne-viscosity, okujongana nokuguquguquka kwemvelaphi kwi-liquid binder ngokwayo.It's rindalomnanded ukuya ukungenai-tallon following positiii-ons:
Binqanawa yokulungiselela ngaphakathi: Imitha ye-ultrasonic ifakwe kumgca kumbhobho wokukhupha okanye kwi-recirculation loop yesitya sokulungiselela i-binder. Oku kubekwa kubamba i-starch paste'uxinaniso ngexesha lokuxuba okanye ukuhlanganisa, ukufumanisa ukungangqinelani okubangelwa kukuguquguquka kwesitatshi sebhetshi ukuya kwibhetshi okanye iimpazamo zokulungiselela.
Isondlo Solwelo kwiGranulator: Imitha ye-ultrasonic ifakwe kumgca womgca wokutya we-binder (ngesiqhelo yipayipi eguquguqukayo okanye ityhubhu yentsimbi engagqwaliyo) phezulu nje kwe-granulator.'i-port yokongeza ulwelo okanye i-spray nozzle assembly. Oku kubekwe emva kwepompo yokutya kodwa phambi kwe-spray lance okanye ingalo yosasazo ngaphakathi kwesitya se-granulator.
