Amashishini e-biotechnology kunye ne-bioprocessing kwihlabathi liphela atshintsha kakhulu ukusuka kwimisebenzi yendabuko esekelwe kwi-batch ukuya kwimveliso eqhubekayo, ezenzekelayo. Ukulinganisa ngexesha langempela kujonga iiparameter zenkqubo ezibalulekileyo ngexesha langempela kwaye kunika inkxaso ekuphuculeni inkqubo ngexesha langempela. Ukulinganisa i-viscosity eqhelekileyo kulawulo lwenkqubo kuxhomekeke kwisampuli eqhutywa ngesandla rhoqo kunye nohlalutyo lwelabhoratri olungaxhunyiwe kwi-intanethi, okwazisa ukungasebenzi kakuhle kunye nemingcipheko ebalulekileyo kwaye kubangele ukulibaziseka kohlengahlengiso lwenkqubo, ukusebenza kakhulu kwemveliso, kunye nokuveliswa kwemveliso engaqhelekanga.
I-Rheology ye-Enzymatic Substrate Degradation
Ulwalamano phakathi kwe-Enzyme ne-Substrate
I-enzyme hydrolysis yinkqubo yokutsala amandla apho i-enzyme inceda ukuqhekeka kwe-molecule ye-substrate eyinkimbinkimbi ibe ziinxalenye ezincinci. Kwimeko ethile ye-cellulase esebenza kwi-polysaccharide ene-molecular-weight ephezulu njenge-carboxymethyl cellulose (CMC), umsebenzi oyintloko we-enzyme kukufaka i-hydrolyze kwi-glycosidic bonds ngaphakathi kwi-long polymer chains. Eli nyathelo liqhekeza i-CMC ngokucwangcisiweyo, linciphisa ubude be-chain kunye nobunzima obuphakathi be-molecular. Iimveliso zale reaction, ikakhulu i-small-chain reducing sugar, ziqokelelana kwisisombululo njengoko inkqubo iqhubeka. Isantya sale degradation sinxulumene ngokuthe ngqo nomsebenzi we-enzyme phantsi kweemeko ezithile zokusebenza zobushushu kunye ne-pH.
Unxibelelwano lweKramers' Theory
Ubudlelwane phakathi komsebenzi we-enzyme kunye neempawu zomzimba ze-reaction medium buyinto ebalulekileyo ekufuneka iqwalaselwe. Ithiyori kaKramers, umgaqo osisiseko kwi-chemical kinetics, ithi iinkqubo ezibandakanya utshintsho lwe-conformation kwiiproteni, ezifana ne-enzyme catalysis, ziphenjelelwa yi-viscosity ye-solvent ejikelezileyo. Njengoko i-solvent viscosity isanda, amandla okungqubana asebenza kwiindawo ze-enzyme zesakhiwo nawo ayanda. Olu ngqubano luphezulu luthintela utshintsho olufunekayo lwe-conformation, lucothisa ngempumelelo umjikelo we-catalytic kwaye lunciphise izinga eliphezulu lokuphendula, okanye i-Vmax.
Ngokwahlukileyo koko, ukwehla kwe-macroscopic viscosity yesisombululo kunciphisa la mandla okungqubana, nto leyo, ngokwethiyori kaKramers, eya kwenza kube lula ukusebenza kwe-enzyme catalytic. Kwimeko yokuwohloka kwe-substrate ye-HMW, umsebenzi we-enzyme ubangela ngokuthe ngqo ukuncipha kwe-viscosity yesisombululo, okudala i-feedback loop apho utshintsho kwi-medium's rheological properties lusebenza njengophawu oluthe ngqo lwempumelelo ye-enzyme.
Ukungena nzulu kwi-Non-Newtonian Rheology
Ukwahlula ii-Newtonian kunye nee-Non-Newtonian Fluids
Indlela esebenza ngayo i-rheological yolwelo ichazwa yi-viscosity yalo kunye nendlela loo mpawu ephendula ngayo kwi-applied shear stress. Kwi-Newtonian fluid, ubudlelwane phakathi kwe-shear stress (τ) kunye ne-shear rate (γ˙) buhambelana ngokuthe ngqo kwaye buhambelana ngokuthe ngqo, kunye ne-constant of proportionality eyi-viscosity (μ). Oku kunokubonakaliswa ngumthetho kaNewton we-viscosity:
τ=μγ˙
Ngokwahlukileyo koko, ulwelo olungelulo olweNewtonian lubonisa ubudlelwane obuntsonkothileyo apho i-viscosity ingaguquguqukiyo kodwa iyahluka ngokwesantya sokucheba. Olu hlobo lokuziphatha luphawuleka kulwelo oluninzi oluntsonkothileyo lwemizi-mveliso, kuquka izisombululo ze-polymer ezifana ne-CMC.
Indlela yokuziphatha ye-HMW Polymer Solutions engeyiyo iNewtonian
Ukuwohloka kweepolymers ze-HMW ngokwemvelo yinkqubo engeyiyo eyeNewtonian. Izisombululo zePolymer ezifana ne-CMC zihlala zibonisa ukuziphatha kokunciphisa ukucheba, apho i-viscosity ebonakalayo iyancipha njengoko isantya sokucheba sisanda. Le nto ibangelwa kukwahlukana kunye nokulungelelaniswa kwee-coils ze-polymer ezinde kwicala lokuhamba, okunciphisa ukungqubana kwangaphakathi kolwelo. Kwiingxinano eziphezulu (umz., ngaphezulu kwe-1%), ezinye izisombululo ze-CMC zinokubonisa nokuziphatha kokuqala kokunciphisa ukucheba, apho i-viscosity inyuka ngesantya sokucheba ngenxa yokwakheka kwe-flow-induced flow associations ze-macromolecular, kulandele ukucheba ukucheba kwizinga eliphezulu lokucheba.
Isenzo se-enzymatic se-cellulase kwi-CMC sitshintsha ngokusisiseko le phrofayili ye-rheological. Njengoko i-enzyme iqhekeza imixokelelwane emide ye-polymer, ubunzima obuqhelekileyo be-molecular ye-substrate buyehla. Oku kuncipha kobude be-chain kunciphisa ngokuthe ngqo inqanaba lokuxinana kunye nokusebenzisana phakathi kwe-molecular. Ngenxa yoko, isisombululo asibi krakra kangako, kwaye iimpawu zaso ezingezizo ze-Newtonian, ngakumbi ukucheba, ziyancitshiswa. Utshintsho olukhulu kwi-bulk rheology yolwelo—ngokukodwa, ukwehla okukhulu kwi-viscosity ngesantya esithile sokucheba—kusebenza njengophawu olucacileyo lokuwohloka okuqhubekayo kwe-enzymatic.
Ubudlelwane boBuninzi bokuxinana kunye nomsebenzi
Ulwalamano phakathi kokwehla kwe-bulk viscosity yesisombululo kunye nokuncipha kobunzima obuphakathi be-molecular yee-substrate molecules lubhalwe kakuhle. Njengoko i-cellulase iqhekeza ii-polymer chain, iziqwenga ezivelayo zinegalelo eliphantsi kakhulu kwi-viscosity iyonke yesisombululo. Olu lwalamano luvumela i-viscosity ukuba isebenze njengommeli onamandla, wexesha langempela wenkqubela phambili ye-enzyme reaction, enye indlela ekhawulezayo ngakumbi kunovavanyo lwelebhu yendabuko olunokungenisa ukulibaziseka okukhulu.
Umlinganiselo oqhubekayo ovela kwi-viscometer ekwi-intanethi usebenza njengeprobe ebukhali kakhulu yolu tshintsho lwesakhiwo. Ukwehla kwe-viscosity ngesantya esithile sokucheba kubonelela ngesalathiso esithe ngqo nesilinganiswayo sobungakanani bokuguqulwa kwe-substrate, kwaye, ngokwandisa, umsebenzi we-enzyme. Esi sisizathu sesayensi sokusebenzisa i-viscometer ye-Lonnmeter-ND njengomlinganiselo oqhubekayo, ongathanga ngqo wenkqubela phambili yempendulo ye-enzyme.
IILonnmeter-ND Vibrating Viscometer
Umgaqo Wokusebenza: Indlela Yokungcangcazela
I-viscometer ekwi-intanethi yeLonnmeter-ND isebenza ngokomgaqo wendlela yokungcangcazela, indlela eqinileyo nethembekileyo yokusetyenziswa kwemizi-mveliso. Into yokuva yesixhobo yintonga eqinileyo evuselelwa kukushukuma nokujika kwicala layo elijikelezayo kwi-frequency ethile. Xa intywiliselwa kulwelo, olu ngcangcazelo luyachaswa yi-viscosity yolwelo, oluyindlela yokulinganisa ukungqubana kwalo kwangaphakathi. Ukumelana kubangela isiphumo sokudambisa okanye ukulahleka kwamandla avela kwi-vibrating element. Isekethe ye-elektroniki ibona oku kulahleka kwamandla, kwaye i-microprocessor iguqula isignali ibe kukufundwa kwe-viscosity. Umlinganiselo oyintloko usekelwe ekuboleni kwe-electromagnetic oscillating waveform, apho isignali ihambelana nemveliso ye-instrument coefficient kunye ne-vibration damping coefficient (λδ).
Le ndlela yahlukile kwezinye iindlela ze-viscometry, ezifana neendlela ze-capillary, i-rotational, okanye i-falling-ball. Ngokungafaniyo nezi ndlela, indlela yokungcangcazela inika ixesha lokuphendula ngokukhawuleza kwaye ayichaphazeleki kakhulu yindawo yokufaka. Ikwayenza lula inkqubo ngokuphelisa imfuneko yokuhamba kweendawo, izitywino, okanye iibheringi.
Iinkcukacha zobugcisa kunye nezakhono
I-viscometer yeLonnmeter-ND yenzelwe ukuhlangabezana neemfuno ezifunekayo zolawulo lwenkqubo yemizi-mveliso. Inika uluhlu olubanzi lokulinganisa i-viscosity oluyi-1 ukuya kwi-1,000,000 cP kwaye ingalungiselelwa imidiya etyebileyo nexineneyo ngokutshintsha imo yesenzi. Ukuchaneka kwesiseko sesixhobo kuchazwe kwi-±2-5% kunye nokuphindaphindwa kwe-±1-2% kwi-Newtonian fluids, nangona isenokubonakalisa rhoqo utshintsho lwe-viscosity kwi-non-Newtonian fluids.
Kwizicelo zobushushu obuphezulu kunye noxinzelelo oluphezulu, i-viscometer ngokubanzi yenziwe ngentsimbi engagqwali engama-316, kunye neendlela ezahlukeneyo zezixhobo ezikhethekileyo ezifana neTeflon okanye iHastelloy kwiimeko ezithile zokusingqongileyo. Ukuze kudityaniswe kwi-bioreactors, inkampani iphuhlise inguqulelo eneprobe yokufakelwa eyandisiweyo, ukusuka kwi-500mm ukuya kwi-2000mm ubude, evumela ukufakwa ngokuthe ngqo ukusuka phezulu ukuya ezantsi kwimithambo yokusabela.
Iingenelo zoYilo lweNdawo eziNgxamisekileyo
Uyilo lweLonnmeter-ND lulungiselelwe kakhulu ukwenziwa kwezinto eziphilayo kwimizi-mveliso. Ixesha layo lokuphendula ngokukhawuleza kunye nokukwazi ukusebenza phantsi kobushushu obuphezulu kunye noxinzelelo kubalulekile kulawulo lwexesha langempela. Ukungabikho kweendawo ezihambayo akunciphisi nje kuphela ukugcinwa kodwa kukwalula ukucoca kunye nokubulala iintsholongwane (ukuhambelana kwe-CIP/SIP), okubalulekileyo ekugcineni iimeko ze-aseptic kwiindawo ze-bioreactor. Uyilo lwento enye evezwe yi-sensor kunye nokungcangcazela okuqhubekayo kwenza ukuba izicoce ngokwayo, ithintele ukuqokelelana kwemveliso kumphezulu we-sensor, okuya kukhokelela ekufundweni okungachanekanga.
Ubuthathaka obuphantsi bendlela yokungcangcazela kwiimeko zokufakela kuthetha ukuba iLonnmeter-ND inokubekwa ngqo kumgca, inika ingxelo eqhubekayo emele ngakumbi iimeko zenkqubo yokwenyani kunesampulu enye yelebhu engaphandle komgca. Ixesha lokuphendula ngokukhawuleza livumela ingxelo ekhawulezileyo, ebalulekileyo ekuthinteleni ukucutshungulwa kakhulu nokuqinisekisa umgangatho wemveliso ohambelanayo. Le theyibhile ilandelayo ishwankathela iinkcukacha zobugcisa eziphambili kunye neziphumo zazo ekusetyenzisweni kwimizi-mveliso.
| Iinkcukacha zoBugcisa | Ixabiso elivela kuxwebhu | Ukubaluleka kweShishini kunye neeNzuzo |
| Indlela yokulinganisa | Indlela yokungcangcazela | Inika impendulo ekhawulezileyo, ayilungiswa kakhulu, kwaye ayivali. |
| Uluhlu lwe-Viscosity | 1 - 1,000,000 cP (ukhetho) | Ukusetyenziswa ngokubanzi kwiintlobo ngeentlobo zeziselo, ukusuka kulwelo olumanzi ukuya kumanzi amdaka atyebileyo. |
| Ukuchaneka Okungavuthwanga | ±2% - ±5% | Ibonisa imfuneko yokulungiswa kwenqanaba lenkqubo kunye nokulungiswa kwedatha ukuze kufezekiswe ukuchaneka okuphezulu. |
| Ukuphindaphinda | ±1% - ±2% | Ibonisa ukuhambelana kwesensor, nto leyo iyimfuneko ephambili yokwenziwa kwemodeli eqhutywa yidatha. |
| Uyilo | Intonga eqinileyo, akukho zinto zishukumayo, izitywino, okanye iibheringi | Inciphisa ukuguguleka koomatshini kwaye yenza kube lula ukucoca, ilungele ukusetyenziswa koxinzelelo oluphezulu/ubushushu obuphezulu. |
| Izinto eziphathekayo | Intsimbi engagqwaliyo engama-316 (esemgangathweni) | Iqinisekisa ukuqina kunye nokumelana ne-corrosive media kwiindawo zeekhemikhali kunye ne-bioprocessing. |
| Ukwenziwa ngokwezifiso | Iiprobe ezinde (500-2000mm) | Ivumela ukufakwa kwe-top-down kwi-reactors ezinee-side opens ezimbalwa, into ebalulekileyo kwiisetingi ezininzi zemizi-mveliso. |
| Imveliso | 4-20mA, RS485 | Ii-interfaces eziqhelekileyo zoshishino zokudibanisa ngaphandle komthungo neenkqubo zolawulo ze-PLC/DCS. |
Ukuhlanganiswa kwedatha kunye nokufunda koomatshini ukuze kuqikelelwe kwangaphambili ngexesha langempela
Idatha yelebhu ye-DNSA ekhawulezileyo kodwa echanekileyo kakhulu idityaniswe nomsinga oqhubekayo wedatha evela kwi-viscometer ye-Lonnmeter-ND kunye nezinye izinzwa zenkqubo ukwenza imodeli yokuqikelela, eqhutywa yidatha. Le ndlela, esebenzisa ii-algorithms zokufunda koomatshini (ML), yindlela yokufezekisa ukuchaneka kwethagethi. Imodeli ye-ML (umz., iiSupport Vector Machines, iGaussian Process Regression, okanye iiArtificial Neural Networks) ifunda ubudlelwane obunzima, obungengomgca phakathi kokufundwa kwe-viscosity kwi-intanethi, ezinye iinguqu zenkqubo (ubushushu, uxinzelelo), kunye nomsebenzi we-enzyme "wokwenyani" njengoko kumiselwe luvavanyo lwe-DNSA.
Le nkqubo yokudibanisa ibaluleke kakhulu. I-sensor enye ichaphazeleka yimithombo eyahlukeneyo yengxolo, kuquka ukuphazamiseka kombane kunye noomatshini, kunye nokushukuma kwe-sensor. Ngoqeqesho kwi-dataset epheleleyo, ene-multi-modal, imodeli ye-ML inokuchonga kwaye ihluze ezi zimpawu zobuxoki. Umzekelo, ukutshintshatshintsha koxinzelelo lwexeshana kunokubangela ukunyuka okufutshane, okungalunganga ekufundweni kwe-viscometer. Imodeli ye-ML, iqonda ukuba le spike ayihambelani notshintsho kubushushu okanye utshintsho oluhambelanayo kwimveliso ye-DNSA, inokungayinaki okanye ilungise ngokwezibalo inqaku ledatha eliphosakeleyo. Oku kuphakamisa ukusebenza kwenkqubo ngaphaya kweenkcukacha eziluhlaza zaso nasiphi na isensor enye.
Ukoyisa Imingeni Yokuphunyezwa Kwemizi-mveliso
Ii-viscometer ezingcangcazelayo, ngokwemvelo yazo, zinovelwano kwiintshukumo zangaphandle zoomatshini kunye nokuphazamiseka kwe-electromagnetic (EMI). Imithombo efana neemoto, iipompo, kunye nezinye izixhobo zasefektri zinokuvelisa ingxolo yoomatshini echaphazela ngokuthe ngqo ukulinganiswa kwe-sensor kokuxinana kwe-viscous, okukhokelela ekufundweni okungachanekanga okanye okuguqukayo. Ngokufanayo, i-EMI, enokutsalwa okanye iqhutywe, inokuphazamisana ne-electronic circuitry ye-sensor, yonakalise isignali kwaye yonakalise ukusebenza.
Izisombululo ezininzi zobunjineli, kwinqanaba lehardware kunye nesoftware, zinokunciphisa ngempumelelo le mingeni. Ngokwembono yehardware, ukufakelwa okufanelekileyo kubaluleke kakhulu. I-sensor kufuneka ibekwe kwindawo eqinileyo, ehlukanisiweyo ne-vibration, kude nemithombo yengxolo ephezulu. Ezinye uyilo lwe-viscometer ziquka "i-balanced resonator" okanye izinto ezifanayo ze-co-axial sensor ezijika kwicala elichaseneyo, zicima ngempumelelo ii-reactions zangaphandle zokufakelwa kwazo.
Kwicala lesoftware, kusetyenziswa ii-algorithms zokucubungula isignali eziphambili ukucoca ingxolo. Indlela ephucukileyo ngakumbi ibandakanya ukusebenzisa isenzi sesibini, njenge-accelerometer yangaphandle, ukulinganisa ukungcangcazela kwangaphandle kwendlu yesenzi. Esi signali "somsindo" emva koko sifakwa kwiprosesa yesignali kunye nesignali ye-viscometer ephambili. Iprosesa isebenzisa i-algorithm yokucoca ukususa isiphumo sokungcangcazela kwangaphandle, ivelise ukufundwa okucocekileyo nokuchanekileyo.ILonnmeterUkusebenzisa kwe-ND indlela yokubola kwe-electromagnetic kunye ne-microprocessor yokuguqula isignali ngokwemvelo kunika umgangatho othile wokucoca kunye nokuqina.
Ukuthembeka kwexesha elide, uLondolozo, kunye neenkqubo ezizimeleyo
Ukugcina idatha ithembekile ngokuhamba kwexesha kubaluleke kakhulu kuyo nayiphi na inkqubo yolawulo lwenkqubo ekwi-intanethi. Zonke izixhobo zokulinganisa ziphantsi "kokushukuma," utshintsho olucothayo ekusebenzeni ngenxa yokuguga koomatshini, ukonakala kwe-elektroniki, okanye izinto ezingqongileyo. Ukuze kuthintelwe oku, kubalulekile ukulinganisa rhoqo nangokusebenzayo.
Indima yeeFluids eziQinisekisiweyo
Ukusetyenziswa kwezixhobo eziqinisekisiweyo zokubhekisa (ii-CRM) ngumgangatho weshishini wokulinganisa ii-viscometer. Ezi zi-fluids, ezidla ngokuba yi-silicone oils, ezibonisa ukuziphatha kwe-Newtonian okuqinisekisiweyo kunye ne-viscosity eyaziwayo kumanqanaba obushushu ahlukeneyo. Ngamaxesha athile, i-viscometer ekwi-intanethi iyasuswa kwinkqubo kwaye iqinisekiswe ngokuchasene nomnye okanye ngaphezulu kwezi migangatho ukuqinisekisa ukuchaneka kwayo. Oku kuqinisekisa ukuba ukusebenza kwesiseko sesixhobo kuyagcinwa kwaye ukufundwa kwaso kuhlala kulandelelwa kwimigangatho yesizwe okanye yehlabathi.
Isakhelo soLondolozo oluQikelelweyo
Ngaphandle kokulungisa nje ukutyibilika, umsinga wedatha oqhubekayo ovela kwi-viscometer ekwi-intanethi ungasetyenziselwa ukuphumeza isicwangciso esibanzi sokugcinwa kwangaphambili. Ukubeka esweni i-fluid viscosity ngexesha langempela kunokusebenza njengesilumkiso kwangethuba kwimiba enokubakho efana nokukhula kwemibhobho okanye ukuvaleka, okuhlala kulandelwa kukutshintsha kwe-fluid rheology. Oku kuvumela abaqhubi ukuba bathathe amanyathelo okuthintela ukucoca okanye ukulungisa inkqubo ngaphambi kokuba kwenzeke ukusilela okukhulu, okonga ixesha lokungasebenzi kunye neendleko.ILonnmeterUyilo lwe-ND olungadingi kulungiswa kakhulu kunye nexesha elikhawulezayo lokuphendula kwenza ukuba ibe yinxalenye engabizi kakhulu nethembekileyo yolu hlobo lwesicwangciso.
Izicelo Zemizi-mveliso kunye Nempembelelo Yeshishini Enokubalwa
Ukuphuculwa kwe-Cellulase Hydrolysis
Eyona ndlela iphambili yokusebenzisa obu buchwephesha kukwenza ngcono i-hydrolysis ebangelwa yi-cellulase kwi-bioreactors yemizi-mveliso. Injongo kukwandisa ukuguqulwa kwe-HMW cellulase/CMC ibe yiswekile enciphisa ixabiso ngelixa kuthintelwa ukucutshungulwa kakhulu, okunokusebenzisa amandla kwaye kunciphise isivuno semveliso iyonke.
Ngokusebenzisa inkqubo edibeneyoILonnmeterInkqubo ye-ND, abaqhubi banokufumana ukufundwa kwe-viscosity okuqhubekayo, ngexesha langempela okuhambelana ngokuthe ngqo nenkqubela phambili yempendulo. Endaweni yokuxhomekeka kwisampulu yesandla kunye novavanyo lwelebhu oluthatha ixesha elide ukufumanisa isiphelo, inkqubo inokupheliswa ngokuzenzekelayo xa ukufundwa kwe-viscosity kwi-intanethi kufikelela kwindawo emiselweyo. Oku kuqinisekisa ukuhambelana kwe-batch-to-batch kwaye kuthintela ukucutshungulwa okugqithisileyo, okukhokelela kumjikelo wemveliso osebenzayo ngakumbi noqikelelweyo. Amandla enkqubo okufikelela ekujoliswe kuwo okuchanekileyo kwe-0.3% aqinisekisa ukuba isiphelo sifezekiswa ngokuchanekileyo okuphezulu, okuqinisekisa umgangatho wemveliso ofanayo.
Ukulinganisa iMbuyekezo yoTyalo-mali (i-ROI)
Ukwamkelwa kobu buchwepheshe kunika imbuyekezo ecacileyo nenokulinganiselwa kutyalo-mali kwiindlela ezahlukeneyo zokulinganisa amashishini.
Imveliso Eyandileyo kunye noMgangatho
Ukukwazi ukujonga nokulawula impendulo ye-enzyme ngexesha langempela kunciphisa inkunkuma kunye nemveliso yemveliso engakhange icwangciswe. Olu lawulo lokuchaneka lukhokelela kwisivuno esiphezulu kunye nemveliso yokugqibela esemgangathweni ophezulu rhoqo, nto leyo echaphazela ngqo ingeniso.
Iindleko Zokusebenza Ezincitshisiweyo
Le nkqubo ayifuni mfuneko yokuthathwa kweesampuli ngesandla kunye nohlalutyo lwelebhu, imisebenzi efuna umsebenzi omninzi kwaye ibiza kakhulu. Ngaphezu koko, ulawulo lwexesha langempela luthintela ukucutshungulwa kakhulu, okunciphisa ukusetyenziswa kwamandla kunye nokusetyenziswa kwee-enzymes ezibizayo. Uyilo oluphantsi lokugcinwa kwe-ILonnmeter-ND inciphisa iindleko zokungasebenzi kunye nokulungisa, nto leyo enegalelo ekongeni imali yokusebenza.
Inkxaso yeSigqibo esiNgcono kunye noHlolo lweZiphoso
Ukusasazwa kwedatha okuqhubekayo okuvela kwi-viscometer, xa kudityaniswe kwinkqubo yokulawula (PLC/DCS), kubonelela ngedatha etyebileyo yohlalutyo oluphambili. Le datha ingasetyenziselwa ukwenza iimodeli kunye nokulinganisa, okuvumela ukwenza izigqibo ezingcono kunye nokuxilongwa ngokukhawuleza kweempazamo. Umzekelo, utshintsho olukhawulezileyo nolungachazwanga kwi-viscosity lunokubonisa ukusilela kwepompo okanye ukungangqinelani kwezinto eziluhlaza, okuvumela isenzo sokulungisa ngokukhawuleza.
Itheyibhile engezantsi inika uhlalutyo oluthelekisayo lwenkqubo ye-viscometric ecetywayo xa kuthelekiswa neendlela zemveli zokuthatha isampuli zelebhu.
| I-Metric | Indlela Yendabuko (Ukuthatha Isampuli Kwilebhu) | Indlela Ecetywayo (ILonnmeter-ND System) |
| Ukufunyanwa kwedatha | Ukuthatha isampuli rhoqo, ngesandla. | Ukubeka esweni okuqhubekekayo, ngexesha langempela kwi-intanethi. |
| Ixesha Lokuphendula | Iiyure ukuya kwiintsuku (ngenxa yezothutho kunye nohlalutyo lwelebhu). | Kwangoko. |
| Ulawulo lweNkqubo | Uhlengahlengiso olulibazisekileyo nolusabela ngokukhawuleza. | Ulawulo olukhawulezileyo nolusebenzayo. |
| Ukungaguquguquki kweMveliso | Iyahluka kakhulu ukusuka kwibhetshi ukuya kwibhetshi. | Ukuchaneka okuphezulu kunye nokungaguquguquki (ujoliso lwe-0.3%). |
| Iindleko zabasebenzi | Eziphezulu (ukuthatha iisampulu ngesandla, iingcali zelebhu). | Inkqubo encinci (ezenzekelayo, ekwi-intanethi). |
| Ixesha lokungasebenzi | Ukwenzeka rhoqo (kwiisampuli, ukugqithisa okunokwenzeka). | Kuncitshisiwe (ukugcinwa kwangaphambili, akukho kulinda iziphumo zelebhu). |
The ILonnmeter-ND, ingaphezulu kakhulu kunesenzi esilula. Xa idityaniswe kwinkqubo ebanzi, eqhutywa yidatha, iba sisixhobo esinamandla nesibalulekileyo sokulawula i-bioprocess.ILonnmeterUyilo lwe-ND oluqinileyo nolungadingi kulungiswa kakhulu kunye nexesha lokuphendula ngokukhawuleza zilungele iimeko ezinzima zokulungiswa kwezinto eziphilayo kwimizi-mveliso.
Ixesha leposi: Septemba-10-2025
