Kutarisa Kuwanda kweStarch muWet Granulation
Starch chinhu chakakosha mukugadzirwa kwemapiritsi nekuda kwekushanda kwayo kwakasiyana-siyana uye kushanda kwayo zvakanaka. Matambudziko mukugadzirwa kwegranulation yakanyorova anotarisana nekudzora kwakakodzera kuwanda kwayo uye hunyoro hwayo. Kuchinja-chinja uku ndiko kunokonzera zvikanganiso zvemhando yepamusoro yechigadzirwa, zvakaita sekutsemuka kwepiritsi, kuchinja kwehuremu, uye kusagadzikana kwekugadzirwa.
Tekinoroji yekuongorora maitiro (Process Analytical Technology (PAT), kunyanya ultrasonic concentration meters), yekutarisa nguva chaiyo, iri mumutsara inodzora concentration ye starch binder, zvichiita shanduko kubva pa paradigm yechinyakare, inopindura, inobva pabvunzo kuenda pa proactive, inobva pakutonga.
Matambudziko eKutarisa Urea Pamhepo
Mabasa Akakosha eStarch muMafomu Emushonga Wakasimba
Starch seMubatsiri weMashandiro Akawanda
Starch imhando yechisikigo, isingakuvadzi, uye isingadhuri, imwe yemishonga inoshandiswa zvakanyanya mumhando dzakasimba dzakadai semapiritsi. Kugona kwayo kuita zvinhu zvakasiyana-siyana ibhenefiti huru, zvichiita kuti ishande mabasa akawanda mukati memushonga mumwe chete, kazhinji ichishanda semusanganiswa wesimbi uye semusanganiswa wemvura mugranulation.
Hunhu hunoshanda hwestarchvarypanobva zvirimwa, zvakaita sechibage, mbatatisi, kana mhunga, izvo zvinosarudza chiyero chayo che amylose-to-amylopectin uye chimiro chayo chegranular. Misiyano iyi inorevesa kuti starch dzinobva kwakasiyana siyana hadzichinjiki. Semuenzaniso, starch yembatatisi inowanzova ne viscosity yakakwira, nepo starch yechibage iine hunhu hwayo hwe pasting. Kunzwisisa hunhu uhwu hwekwakabva kwakakosha pakugadzira fomura.
Tafura inotevera inopfupikisa hukama huripo pakati pezvinhu zvakasiyana-siyana zvestarch nemabasa azvo:
| Chitubu cheStarch | Chiyero cheAmylose/Amylopectin | Zvimiro Zvikuru Zvebasa | Hunhu hweFizikiki neKemikari |
| Chibage | Inenge 27:73 | Binder, disintegrant, filler | Kupisa kwegelatinization, viscosity yepakati |
| Mbatatisi | Inenge 22:25 | Yakasiyana, yekuzadza | Kupisa kwakaderera kwegelatinization, viscosity yakakwira |
| Mazambiringa | Inenge 19.2:80.8 | Chinosunga, chakaparara | Kuparara nekukurumidza, mwero wekuparara wakakwira |
Une mibvunzo nezve kugadzirisa maitiro ekugadzira？
Tsananguro yeMagadzirirwo eChiito cheStarch
Starch seBinder: Kukosha kweGelatinization
Starch inoshanda semushonga unoshanda mukunyorova kwegranulation nekuda kwegelatinization, maitiro apo kupisa nemvura zvinokanganisa chimiro chayo chekristaro zvisingadzoreki. Starch yemuno, iyo isinganyungudike mumvura inotonhora, inoda danho iri rekubika kuti inyorovese amylose neamylopectin polymers, zvichiita kuti zvikwanise kubatana.
Maumbirwo eAmylopectin ane matavi akawanda, akafanana nemuti anopa nzvimbo dzakawanda dzekubatanidza, zvichiita kuti ibatanidze zvidimbu pamwe chete zvinobudirira. Panguva iyi, amylose, nechimiro chayo chakarongeka, inowedzera viscosity uye inoita network yegel painotonhora, zvichisimbisa kugadzikana kwegranule.
Kuti zviite nyore kugadzira zvinhu zvemaindasitiri uye kubvisa kudiwa kwekubika, mastachi akabikwa kare akagadzirwa. Mastachi aya, akabikwa zvishoma kana zvizere, anonyungudika mumvura inotonhora uye anogona kuwedzerwa seupfu hwakaoma mumafomura. Munguva yegranulation, mvura inoaita kuti ashande aripo, zvichiita kuti kugadzirwa kuve nyore ukuwo ichisimbisa kushanda kwakasimba kwekubatanidza.
Starch seDisintegrant: Kuzvimba uye Kupwanya
Starch inongoerekana yaparara, ine mashandiro ayo makuru ekuzvimba. Kana piritsi rikasangana nechinhu chinoyerera mvura, mvura inopinda mudumbu repiritsi rine maburi kuburikidza nekuita kwe capillary (wicking). Ma granules e starch anotora mvura yacho ozvimba kusvika pahuwandu hwayo hwepakutanga. Kumanikidzwa kwemukati kunokonzerwa nekuzvimba uku kwakakwana kukunda masimba ekubatanidza piritsi uye kuita kuti riparare kuita zvidimbu zvidiki.
Kushanda kwestarch sechinhu chinoparara kunokonzerwa nezvinhu zvakaita sekuwanda kwayo, saizi yezvikamu, uye simba rekumanikidza rinoshandiswa. Chinhu chikuru chakawanikwa ndechekuti kunyange zvazvo kuzvimba kuri iko kunonyanya kuita basa, zvimwe zviitiko, zvakaita sekudzora pakati pezvikamu uye kukanganiswa kwehydrogen bonds, zvinobatsirawo mukuparara.
Matambudziko muWet Granulation of Tabregai
Kuwanda kweStarch uye Hunyoro
Kuchinja-chinja kwehuwandu hwestarch paste kana hunyoro hwemusanganiswa weupfu ndizvo "zvinorwadza" zvikuru mu granulation yakanyorova. Kushanda kwestarch se binder kunoenderana zvikuru nekugadzirwa kwayo. Semuenzaniso, kana starch paste "isina kubikwa zvakakwana," haizoshande se polymer inobatanidza inoshanda nekuti chimiro chayo che crystalline chinoramba chakasimba.
Basa rehunyoro rakaoma. Pahuwandu hwakaderera, mvura inogona kushanda semafuta, zvichivandudza kuyerera kwemvura. Zvisinei, kana hunyoro hwacho hukadarika padanho rakakosha, hunowedzera kubatana kwepakati pezvikamu nekugadzira maburiji akasimba emvura, izvo zvinoderedza kuyerera kwemvura. Izvi zvinogona kutungamira mukusakwana uye kusagadzikana kwekuzadza kwemvura panguva yekumanikidzwa kwepiritsi, zvichikonzera kusiyana kwehuremu hwepiritsi.
Hukama uhwu hunoita kuti pave nekushanda kwakawanda. Kusafamba zvakanaka kwemvura nekuda kwekushanduka kwehunyoro hakungogumiri pakuenzana kwehuremu asiwo kunokanganisa kuenderana kwesimba rekumanikidza, zvichikonzera kupararira kukuru kwekuoma kwepiritsi uye kuwanda kwaro, uye pakupedzisira zvichikanganisa mashandiro ekunyungudika. Izvi zvinoratidza hukama hwakaoma pakati pehunhu hwemhando hunoita sehusina hukama.
Dzidza NezveMamwe Mamita Ehuremu
Matambudziko Ekugadzirisa Maitiro
Kusakwana kwehuwandu hwema "binder" kana kusakwana kwe "starch polymer" kunogona kukonzera ma "granules" asina kusimba uye, nekudaro, mapiritsi "akapfava" anowanzo putika nekutsemuka. Kusiyana neizvi, huwandu hwakawanda hwema "binder" kana kuti ma "granulation" akawanda zvinogona kugadzira ma "granules" akaomarara, izvo zvinogona kukonzera zvikanganiso zvakaita sekutsemuka nekukanda panguva yekumanikidzwa kwepiritsi nekuda kwekuvharwa kwemhepo uye kusakwana kwekuchinja kwepurasitiki.
Maitiro ekugadzira granulation yemvura anonyanya kukanganiswa nezvinhu zvakaita senguva yekukanda granulation yemvura uye kumhanya kweimpeller, izvo zvinogona kukonzera granulation yakawandisa uye kuwedzera kwehuwandu hwegranule. Iri idambudziko guru.
Chinhu chinonyanya kucherechedzwa ndechekuti hapana hukama hwakafanana pakati pesimba remagranule nesimba rekudhonza mapiritsi. Pfungwa yakajairika ndeyekuti magranule akasimba, akasimba—akagadzirwa, semuenzaniso, negranulation yakanyanya kuchekwa—anofanira kubereka mapiritsi akasimba. Zvisinei, humbowo hunoratidza kuti magranule akagadzirwa negranulation yakanyanya kuchekwa, nepo ari iwo akanyanya kusimba uye akasimba, anokonzera mapiritsi ane simba rakaderera rekudhonza mapiritsi. Izvi hazvisi kupokana kuri nyore. Zvinoratidza kuti kunyangwe kubatana kwemukati megranule kungave kwakasimba, zvisungo zvepakati pegranule zvinoumbwa panguva yekudzvanywa kwepiritsi hazvina kusimba. Izvi zvinodaro nekuti magranule akakora haana kusimba uye haanyatso shanduka kana achidzvanywa. Kuderedzwa kwekushanduka uku kunoderedza nzvimbo yekubatana pakati pemagranule uye kunoderedza kuumbwa kwemabhiriji akasimba, zvichikonzera piritsi rekupedzisira risina kusimba kunyangwe simba remagranule pacharo. Saka, kudzora granulation endpoint hakusi kwekuwedzera simba remagranule kana density, asi nezvekuwana chiyero chakakodzera chinoita kuti piritsi rekupedzisira rifambe zvakanaka uye rikwanise kudzvanywa zvakakwana kuti rigadzire piritsi rekupedzisira rakasimba.
Kukanganiswa kweStarch Concentration paHunhu hwekupedzisira hweChigadzirwa
Kuoma uye Kusagadzikana
Kuwedzera huwandu hwemabinder kunowanzoita kuti mapiritsi ave akaomarara uye akwanise kupwanyika zvishoma. Starch inopa hunhu hwekubatana huri pakati nepakati zvichienzaniswa nemapolymers ekugadzira akadai sePVP, anowanzo buritsa mapiritsi akapfava asi aine hunhu huri nani hwekuparara. Imwe ongororo yakaitwa pastarch yechibage yakagayiwa kare yakawana kuti huwandu hwemabinder hunobva pa3% kusvika 9% ndiyo yaive nzira yakanakisisa yekuwana hunhu hwakanaka hwemuviri hunogamuchirwa.
Kuparara uye Kuparara
Pane hukama hwakajeka pakati pekuwanda kwestarch binder uye mwero wekunyungudika kwemushonga. Sezvo huwandu hwemabinder huchiwedzera, mapiritsi anooma uye nguva yekuputsika kwawo inowedzera, izvo zvinononotsa kuburitswa kwechinhu chinoshanda chemishonga (API).
Kunonoka uku kwestarch pakunyungudika kunogona kutsanangurwa nehunyanzvi nekuumbwa kwe "leached layer". Kana piritsi rine starch rikasangana ne dissolving medium, starch iri pamusoro pepiritsi inozvimba uye inoumba viscous, yakafanana negel layer. Iyi gel layer haina API zvakanyanya. Nekuda kweizvozvo, API inonyungudika kubva pakati pepiritsi inofanira kupararira kuburikidza neiyi viscous, stuffed starch matrix kuti isvike pa bulk dissolving medium. Iyi disfusion process inhanho inononoka, inoganhurira mwero.
Ukobvu uye kusimba kwechikamu ichi chakachekwa zvinoenderana nehuwandu hwestarch uye mwero we gelatinization. Nokudaro, kusagadzikana kwehunhu hwestarch kana huwandu hwayo kunotungamira zvakananga kuma profiles akasiyana-siyana ekunyungudika, inova chinhu chakakosha chemhando (CQA) chinokanganisa bioavailability yemushonga.
Kuwanda kweGranule uye Mapiritsi
Zviyero zvakakosha zvekuongorora hunhu hwegranule zvinosanganisira kuwanda kwehuwandu hwegranule, kuwanda kwehuwandu hwegranule, uye Compressibility Index (CI). Zvidzidzo zvakaratidza kuti nguva refu yekunyorova kana kumhanya kwakanyanya kweimpeller kunowedzera kuwanda kwegranule nekuda kwekubatanidzwa kwakanyanya.
Kuwanda uku, kunyange zvazvo kuchivandudza kuyerera kwemvura, kunoita kuti granules dzive shoma, zvichireva kuti granules dzakaoma kudzvanya. Nekuda kweizvozvo, piritsi rekupedzisira rinogona kunge risina simba kupfuura zvaitarisirwa kana kuti rinoda simba rakawanda rekudzvanya, izvo zvinogona kukonzera kusakara kwemidziyo kana matambudziko akadai sekutsemuka kwepiritsi. Izvi zvinogadzira nzira yakaoma yekupindura apo maitiro madiki anochinja, sekuwedzera kudiki kwehuwandu hwestarch, kunogona kuva nemhedzisiro yakakosha uye isingafungidzike pamhando yechigadzirwa chekupedzisira.
| Kuwanda kweStarch Binder (% w/w) | Kuoma kwepiritsi (N) | Kugadzikana kwepiritsi (%) | Nguva yekuparara |
| 0% | Hapana Chinosunga | Hazvina kukwana | Hazvina kukwana |
| 3% | 20 - 30 | <1% | Hazvibvi pasimba rekumanikidza |
| 6% | 20 - 30 | <1% | Hazvibvi pasimba rekumanikidza |
| 9% | 20 - 30 | <1% | Hazvibvi pasimba rekumanikidza |
| 15% | 20 - 30 | <1% | Inowedzera nesimba rekumanikidza |
Cherechedza: Hunhu hwekuoma hunobva padata resimba rekumanikidza rakati.
Kukosha kweKutarisa Kwakarurama Munguva Yechokwadi
Miganhu Yekudzora Hunhu Hwechinyakare
Nzira dzechinyakare dzekudzora hunhu, dzakadai sekuongorora granules kana mapiritsi akaomeswa pasina internet kana pa-line, dzinoshanda zvakanyanya. Dzinovimba nekutora sampuli nekuyedza zvinotora nguva, dzisingape mhinduro chaiyo pane zviri kuitika. Kunonoka kwenguva uku kunoita kuti zvisakwanise kudzivirira kugadzirwa kwemapoka asingaenderane nezvinodiwa, zvichikonzera kurasika kukuru kwezvinhu uye kurasikirwa nemari.
Mhinduro yekutarisa kuzara kweStarch
Mamita ekuyera eUltrasonickuona huwandu kana kuti kuwanda kwemvura nekuyera kumhanya kunoita ruzha nekufamba kwarwo. Kumhanya kweruzha kunoenderana zvakananga nehunhu hwemvura, kusanganisira kuwanda kwayo nekupisa kwayo.
Iyi tekinoroji yakakodzera kwazvo maitiro emishonga nekuda kwezvakanaka zvayo:
- Hazvipindi muropa:Sensor haina zvikamu zvinofamba uye inogona kuiswa mupombi kana mudziyo, zvichipa zviyero zvenguva chaiyo pasina kukanganisa kufamba kwemaitiro.
- Kusasarura:Kuyerwa hakukanganisike neruvara rwechinwiwa, kujeka kwacho, kana mwero wekuyerera kwacho, izvo zvinova zvipingamupinyi zvinowanzoitwa pakushandisa nzira dzekuona.
- Zvakananga uye zveMakanika:Inoyera zvakananga huwandu hwestarch paste, chinhu chakakosha chinobatanidzwa nehukuru hwechigadzirwa chekupedzisira.
Nzvimbo yekuisa yeOnline Ultrasonic Concentration Meter
Kuiswa kwacho kunotarisa pakugadzirira binder uye kuwedzera chikamu, chinoitika pakarepo mushure mekusanganisa upfu hwakaoma asi usati wanyorova. Kuiswa uku kunobvumira kugadziriswa kwehuwandu hwestarch paste uye viscosity, zvichigadzirisa kusiyana kwemidzi ye liquid binder pachayo.It's rzvakatipoteredzaamainded ku installon following positimaon:
Bngarava yekugadzirira mukati: Chiyero che ultrasonic chinoiswa pamutsetse papombi yekubuditsa kana padenderedzwa remhepo yemudziyo wekugadzirira binder. Kuiswa uku kunobata starch paste's panguva yekusanganisa kana homogenization, kuona kusawirirana kunokonzerwa nekusiyana kwestarch kubva pabatch kuenda pabatch kana zvikanganiso zvekugadzirira.
Kupa Granulator Mvura: Chiyero che ultrasonic chinoiswa mumutsara we binder feed line (kazhinji ipaipi inochinjika kana chubhu yesimbi isina ngura) chiri kumusoro kwe granulator.'s liquid addition port kana spray nozzle assembly. Izvi zvinoiswa mushure mepombi yekudyisa asi pamberi pespray lance kana distributor arm mukati me granulator bowl.
