Kutarisa nekudzora mashandiro ekubikisa zvinoreva kugadzira nzvimbo yakakwana yekukura nekuvirisa hutachiona, wobva wachengetedza kushanda zvakanaka, goho rakanaka uye mhando yechigadzirwa inoenderana. Zviyero zvikuru zvakaita se pH, okisijeni yakanyungudutswa, tembiricha, huwandu hwe substrate, viscosity zvese izvi zvinosarudza mhando uye kushanda zvakanaka mumafekitori emishonga, umo zvinodiwa zvakasimba zvinoiswa pamberi pemutsara wekuita.
Zvinodiwa Pakuvirisa Muto Kusviba & Kutarisa Kuomerera
Kuwanda kwemasero uye kusviba kwemuviri zvinoshanda sechiratidzo chekukura kwehutachiona, kuwanda kwemasero, uye kuumbwa kwemuto, zvichikanganisa zvakanyanya zvinhu zvakakosha zvakaita sekufambiswa kwehuwandu, kuwanikwa kweokisijeni, uye kugoverwa kwezvinovaka muviri. Pasina kutarisa kwakanyatsonaka kwekuvirisa uye kudzora maitiro ekuvirisa, kuchinja kwehuwandu nekusviba kwemuviri kunogona kukanganisa kuenzana kwakanaka kwenzvimbo yekuvirisa, zvichikonzera kudzikira kwegoho, kusagadzikana kwemhando yechigadzirwa, uye kusashanda zvakanaka kunodhura.
Kugara uchitarisa maitiro ekuvirisa zvirimwa online kunopa ruzivo rwechokwadi, zvichipa simba kune vanobika kuti vagadzirise nekukurumidza uye nemazvo zvinhu zvakaita sehuwandu hwezvinovaka muviri uye mwero wemhepo. Bvisa migumisiro yakaipa inounzwa nekunonoka uye kutora nguva yakawanda kwekutora sampling nemaoko.
Pfupiso yePenicillium Fermentation Process
Kuvirisa mishonga ipurojekiti yakaoma ye microbiology uye engineering, uko tupukanana twakagadzirwa zvakanaka, senge mabhakitiriya kana fungus, tunogadzira zvinhu zvakakosha zvakaita semishonga inorwisa mabhakitiriya, majekiseni, uye ma enzymes.
Maitiro ekuvirisa penicillium anotangira pakugadzirira inoculum mumatangi embeu. Wobva wachinja kuita fed-batch fermentation mumidziyo ine zvinovaka muviri mukati memidziyo mikuru yefermentors yakadzika, kusanganisira michina iri pasi pemvura yekudzoreredza nekuchenesa. Kuwanda kwemuto wekuvirisa uye viscosity zvinogara zvichitariswa uye zvichidzorwa uchishandisa inline process sensors, internal model controllers, uye automated systems kuwedzera goho nekudzivirira kusvibiswa.
Hunhu hwePenicillium Chrysogenum muBatch Fermentation yekugadzirwa kwePenicillin
Penicillium chrysogenum, fungus ine filamentous, ndiyo tupukanana tunosarudzwa mukugadzirwa kwepenicillin mumaindasitiri. Maitiro ayo panguva yekuvirisa akaomarara uye anokanganisa zvakananga kushanda zvakanaka uye goho remushonga wekupedzisira. Kunzwisisa hunhu hwayo kwakakosha kuti pave nekudzora mashandiro emushonga zvinobudirira.
Munguva yekuvirisa, viscosity uye concentration zvakabatana, uye shanduko mune chimwe chinokanganisa zvakananga chimwe. Hukama uhwu chinhu chakakosha pakudzora maitiro, sezvo huchikanganisa zvese kubva pakukura kwehutachiona kusvika pakubereka kwechigadzirwa.
Kuchinja kweViscosity
Kusimba kwemuto wekuvirisa kunoratidza kuti haugone kuyerera zvakanaka. Haugari kwenguva refu uye unowanzo shanduka panguva yekuvirisa nekuda kwezvikonzero zvakasiyana-siyana:
Kuwanda kwetupukanana tunowedzera nekukura kwatwo uye tunowanda mukukura kwebiomass. Kuvapo kwemuviri chete ndiko kunoita kuti masero asanganiswe, izvo zvinoita kuti muto wekuvirisa uwedzere kusimba zvakanyanya.
Kupera kwemasero kunoitika panopera kuviriswa kwemasero. Utachiona hunogona kupera kana masero akamanikidzwa, zvichiburitsa zvinhu zviri mukati memasero zvakaita seDNA nemapuroteni. Mamorekuru aya makuru anogonawo kuwedzera zvakanyanya kunaka kwemuto.
Kuchinja Kwekutarisisa
Kuwanda kwemasero kunochinja-chinja kana mabhakitiriya achiwanda sezvo kuwanda kwemasero kuchikonzera muto wakazara uye kusangana kwakawanda pakati pemasero. Ehe, kuwanda kwekutanga kwezvinhu zvakaita seshuga nezvinovaka muviri kune mhedzisiro yakajeka pakukura kwehutachiona.
Mapuroteni anoburitswa uye polysaccharide zvinoungana mukubikisa nguva dzose, zvichibatsira kuwedzera huwandu hwezvinhu zvakanyungudutswa kana zvakamiswa.
Mhedzisiro yeUkama
Hukama hwepedyo huripo pakati pekusviba nekuwanda kwechinhu hune zvahunoreva pakuita kwekuvirisa. Kuwedzera kwekusviba nekuda kwekuwedzera kwekuwanda kwechinhu kunogona:
Kutadzisa Kutamiswa Kwematumbu: Kuoma kwakanyanya kunoita kuti zviome kutamisa magasi akakosha senge oxygen kubva mumabubble emhepo kuenda mumuto, zvichideredza kugona kwehutachiona kukura.
Deredza Kushanda Zvakanaka Pakusanganisa: Muto wakakora unoda simba rakawanda kuti usanganiswe zvinobudirira. Izvi zvinogona kutungamira kunzvimbo dzisingagari apo zvinovaka muviri zvinopera uye marara anoungana, zvichiita kuti pave nenzvimbo isina kuenzana inokanganisa kubereka.
Kukanganisa Kugadzirwa Kwemvura: Muto une viscous zvakanyanya unonetsa kusefa, kutenderedza, uye kuchenesa panguva yekudzoreredza chigadzirwa, zvichiita kuti maitiro ese asashande zvakanaka uye adhure zvakanyanya.
Saka, kutarisa kunaka uye kutarisisa zvinhu panguva chaiyo kwakakosha pakuchengetedza mamiriro akanaka, kuona kuti chigadzirwa chacho chinoenderana, uye kuwedzera goho.
Mashandisirwo eInline Viscosity Monitoring
Kugona kuchinja kwekutarisa kwepamhepo mukuita kwekuvirisa kunoonekwa zvakanyanya mukugadzirwa kwemishonga inorwisa mabhakitiriya, senge penicillin. Kutevera viscosity panguva chaiyo kunobvumira vashandisi kuona kukura kwehutachiona uye kuenderana kwemuto, zvichigonesa kugadzirisa kwakanyatsojeka nzira dzekudyisa, mhepo, uye kumutsa.
Matekinoroji ekugadzira zvinhu otomatiki anoshanda semuchenjedzi asati asangana nezvikanganiso, kusvibiswa, uye kuumbwa kwefuro kudzivirira tsaona dzekugadzira. Uyezve, zvinoita kuti zvikwanise kukura kubva murabhoritari kuenda kumaindasitiri.
Mhinduro dzeKuyera Kuyerwa kweLonnmeter Inline Viscosity
Mabasa Makuru uye Magadzirirwo Ehunyanzvi
Viscometer yekuchenesa iri mukati uyemita yekuyera kuwanda kwemishongadzakagadzirirwa kutarisa kuviriswa kwemuriwo uye kudzora maitiro ekushandisa mishonga. Dhizaini yadzo yemuchina inoderedza mikana yekuungana kwebhakitiriya, kugadziriswa nguva dzose uye kutotsiva.
Izvizviridzwa zvekushandisa otomatiki zviri mukatiinopa kuyerwa kwekusimba uye kusimba kwemuviri panguva chaiyo, zvichiita kuti muto uve wakafanana mu bioreactors. Viscometer yekuchenesa iri mumutsara ine huwandu hwe10–10000,000 cP. Kushivirira kwayo tembiricha kunosvika 350°C.
Zvine masensa epamusoro-soro anotenderera kana kuti anonzwika, zvishandiso izvi zvinopa kuverenga kwakanyatsojeka mumamiriro ezvinhu anochinja-chinja uye zvinobatana zvakanaka nePLC neDCS systems kuti dzidzore otomatiki, zvichiita kuti zvive zvakanaka pakubikwa kwepenicillin.
Zvakanakira Nzira Dzechinyakare Dzekusashandisa Internet
Zvishandiso zvekuyera viscosity zveLonnmeter zviri mukati memutsara zvinokunda nzira dzechinyakare dzekushanda pasina internet. Zvishandiso zvepamusoro zvinogonesa kugadzirisa maitiro nekukurumidza, zvichibvisa zvikanganiso zvesampuli.
Kunyatsoshanda kwavo nemazvo mukubata muto usiri weNewtonian kunopfuura zvishandiso zvisiri zvemumba, izvo zvinowanzo kundikana kana zvikashandiswa zvine mvura yakaoma. Magadzirirwo ehutsanana anoderedza njodzi dzekusvibiswa, zvakakosha munzvimbo dzemishonga, nepo kuunganidzwa kwedata otomatiki kunoderedza kukanganisa kwevanhu, zvichiita kuti kuve kwakavimbika pakutarisa maitiro ekuvirisa online.
Mabhenefiti muKugadzira Maitiro Ekuvirisa
Mhinduro dzeLonnmeter dzinoshandura otomatiki mukuvirisa kwepenicillin nguva dzose, zvichipa mabhenefiti asina muganho. Dzinovimbisa kusimba kwemuto wekuvirisa nguva dzose, zvichikonzera kuberekana kwepenicillin kwakafanana uye kuchena kwakanyanya.
Kudzora viscosity otomatiki kunoderedza marara, kushandiswa kwesimba, uye nguva yekushanda, zvichikonzera kuchengetedza mari yakawanda. Data renguva chaiyo rinogonesa kugadzirisa mwero wekudya, mhepo, uye kumutsa, zvichiita kuti mashandiro abudirire.
Kukosha kukuru kwekutarisa inline viscosity mukuvirisa mishonga, kunyanya pakuvirisa penicillin, hakufanirwe kutaurwa zvakanyanya. Isa maitiro ako ekuvirisa padanho rinotevera—taura naLonnmeter nhasi kuti ukumbire mutengo wakagadzirirwa iwe pachako wemhinduro dzedu dzepamusoro dzekuyera viscosity uye kuvhura kunyatsogadzirwa kusingaenzaniswi!
Nguva yekutumira: Nyamavhuvhu-14-2025
