Kev Soj Ntsuam Qhov Muaj Hmoov Nplej Hauv Kev Ua Granulation Uas Nqus Tau
Hmoov txhuv nplej siab yog ib qho tseem ceeb hauv kev tsim cov ntsiav tshuaj vim nws muaj ntau yam siv tau thiab pheej yig. Cov teeb meem hauv cov txheej txheem ua cov granule ntub yog nyob ntawm kev tswj hwm qhov tseeb ntawm nws cov concentration thiab cov dej noo. Cov kev hloov pauv no yog qhov ua rau muaj qhov tsis zoo ntawm cov khoom lag luam, xws li cov ntsiav tshuaj tawg, qhov hnyav hloov pauv, thiab kev yaj tsis sib xws.
Cov Txheej Txheem Tshawb Fawb Txog Kev Ua Haujlwm (PAT), tshwj xeeb yog cov ntsuas ultrasonic concentration, rau lub sijhawm tiag tiag, kev saib xyuas hauv kab tswj cov hmoov txhuv nplej siab qhov concentration, ua qhov hloov pauv ntawm ib txwm muaj, reactive, raws li kev sim mus rau ib qho proactive, raws li kev tswj hwm.
Cov Teeb Meem ntawm Kev Saib Xyuas Urea Hauv Online
Lub Luag Haujlwm Tseem Ceeb ntawm Starch hauv Cov Ntawv Khob Khob
Starch ua ib qho khoom siv ntau yam
Hmoov txhuv nplej siab yog ib yam khoom ntuj tsim, tsis muaj tshuaj lom, thiab pheej yig, yog ib qho ntawm cov khoom siv feem ntau siv hauv cov ntawv khov xws li cov ntsiav tshuaj. Nws qhov kev hloov pauv tau yog qhov zoo tseem ceeb, ua rau nws ua tau ntau yam haujlwm hauv tib daim ntawv, feem ntau ua haujlwm ua tus khi thiab tus yaj hauv cov granules ntub.
Cov yam ntxwv ua haujlwm ntawm cov hmoov txhuv nplej siabvaryntawm nws cov khoom siv botanical, xws li pob kws, qos yaj ywm, lossis sorghum, uas qhia nws qhov sib piv amylose-rau-amylopectin thiab granular morphology. Cov kev sib txawv no txhais tau tias cov hmoov txhuv nplej siab los ntawm ntau qhov chaw sib txawv tsis tuaj yeem hloov pauv tau. Piv txwv li, hmoov txhuv nplej siab feem ntau muaj viscosity siab dua, thaum hmoov txhuv nplej siab muaj nws cov yam ntxwv tshwj xeeb ntawm kev nplaum. Kev nkag siab txog cov khoom tshwj xeeb ntawm qhov chaw no yog qhov tseem ceeb rau kev tsim cov qauv.
Cov lus hauv qab no piav qhia txog kev sib raug zoo ntawm cov hmoov txhuv nplej sib txawv thiab lawv lub luag haujlwm:
| Qhov chaw ntawm cov hmoov txhuv nplej siab | Qhov piv ntawm Amylose/Amylopectin ib txwm muaj | Cov Khoom Tseem Ceeb Ua Haujlwm | Cov yam ntxwv ntawm lub cev thiab tshuaj lom neeg |
| Pob kws | Kwv yees li ntawm 27:73 | Cov khoom siv khi, cov khoom tawg, cov khoom sau | Kub ntawm gelatinization, viscosity nruab nrab |
| Qos yaj ywm | Kwv yees li ntawm 22:25 | Disintegrant, filler | Qhov kub gelatinization qis, viscosity siab |
| Sorghum | Kwv yees li ntawm 19.2:80.8 | Cov khoom siv khi, cov khoom tawg | Kev yaj sai dua, cov nqi yaj siab dua |
Muaj lus nug txog kev ua kom zoo dua cov txheej txheem tsim khoom?
Kev piav qhia txog kev ua haujlwm ntawm Starch
Starch ua ib qho Binder: Qhov Tseem Ceeb ntawm Gelatinization
Hmoov txhuv nplej ua haujlwm ua ib qho khoom sib txuas zoo hauv kev sib xyaw ua ke vim yog gelatinization, ib qho txheej txheem uas cua sov thiab dej cuam tshuam nws cov qauv crystalline. Hmoov txhuv nplej hauv paus, uas tsis yaj hauv dej txias, xav tau cov kauj ruam ua noj no kom hydrate nws cov amylose thiab amylopectin polymers, ua rau lawv muaj peev xwm sib txuas.
Amylopectin cov qauv uas muaj ceg ntoo zoo li tsob ntoo muab ntau qhov chaw txuas, ua rau nws tuav tau cov khoom me me ua ke. Lub caij no, amylose, nrog nws cov qauv linear, ua rau viscosity ntau dua thiab tsim cov gel network thaum nws txias, ua kom cov granule ruaj khov.
Yuav kom ua kom cov txheej txheem kev lag luam yooj yim dua thiab tshem tawm qhov xav tau kev ua noj, cov hmoov txhuv nplej siab uas tau ua ntej gelatinized tau tsim. Cov hmoov txhuv nplej siab no, ib feem lossis tag nrho gelatinized, yaj rau hauv dej txias thiab tuaj yeem ntxiv ua hmoov qhuav rau cov mis. Thaum lub sijhawm granulation, dej ua rau lawv ua haujlwm hauv qhov chaw, ua kom yooj yim rau kev tsim khoom thaum ua kom muaj kev sib txuas zoo.
Starch ua ib qho Disintegrant: O thiab Wicking
Hmoov txhuv nplej yog ib yam khoom uas ua rau cov khoom tawg yooj yim, thiab nws txoj kev ua haujlwm tseem ceeb yog o. Thaum ib lub ntsiav tshuaj kov cov dej, dej nkag mus rau hauv cov ntsiav tshuaj uas muaj qhov porous los ntawm kev ua haujlwm capillary (wicking). Cov hmoov txhuv nplej nqus dej thiab o mus rau ntau npaug ntawm nws qhov ntim qub. Lub siab sab hauv uas tsim los ntawm qhov o no txaus kom kov yeej lub zog khi ntawm lub ntsiav tshuaj thiab ua rau nws tawg ua tej daim me me.
Qhov ua tau zoo ntawm cov hmoov txhuv nplej siab ua cov khoom tawg yog cuam tshuam los ntawm cov yam xws li nws qhov kev sib sau ua ke, qhov loj ntawm cov khoom me me, thiab lub zog nias uas siv. Ib qho tseem ceeb uas pom tau yog tias thaum o yog lub hauv paus tseem ceeb, lwm yam xwm txheej, xws li kev cuam tshuam ntawm cov khoom me me thiab kev cuam tshuam yooj yim ntawm cov hydrogen bonds, kuj pab txhawb rau kev tawg.
Cov teeb meem hauv kev ua Granulation ntub of Tabcia
Kev Ntsuas Hmoov Nplej thiab Cov Dej Nqus
Qhov kev hloov pauv ntawm qhov concentration ntawm cov hmoov txhuv nplej siab lossis cov dej noo ntawm cov hmoov sib tov yog cov "qhov mob" loj hauv kev ua granulation ntub. Kev ua tau zoo ntawm cov hmoov txhuv nplej siab ua tus binder yog nyob ntawm nws txoj kev npaj. Piv txwv li, yog tias cov hmoov txhuv nplej siab "tsis siav txaus," nws yuav tsis ua haujlwm ua cov polymer binder zoo vim nws cov qauv crystalline tseem zoo li qub.
Lub luag haujlwm ntawm cov dej noo yog qhov nyuaj heev. Thaum cov dej tsawg, dej tuaj yeem ua haujlwm ua cov roj nplua nyeem, txhim kho kev ntws. Txawm li cas los xij, thaum cov dej noo ntau dua qhov tseem ceeb, nws ua rau muaj kev sib koom ua ke ntawm cov khoom me me los ntawm kev tsim cov choj kua muaj zog, uas txo qhov ntws. Qhov no tuaj yeem ua rau tsis txaus thiab tsis sib xws ntawm cov pwm thaum lub sijhawm nias ntsiav tshuaj, ua rau qhov hnyav ntsiav tshuaj sib txawv.
Qhov kev sib raug zoo no tsim kom muaj qhov cuam tshuam domino. Kev ntws tsis zoo vim muaj kev hloov pauv ntawm cov dej noo tsis yog tsuas yog cuam tshuam rau qhov hnyav sib npaug xwb tab sis kuj cuam tshuam rau qhov sib xws ntawm lub zog nias, ua rau muaj kev faib tawm dav dav ntawm qhov nyuaj thiab qhov ceev ntawm cov ntsiav tshuaj, thiab thaum kawg cuam tshuam rau kev ua haujlwm yaj. Qhov no qhia txog qhov sib txuas ntawm cov yam ntxwv zoo uas zoo li tsis muaj feem cuam tshuam.
Kawm Txog Ntau Cov Ntsuas Qhov Ceev
Cov Teeb Meem Mob ntawm Cov Txheej Txheem
Qhov kev sib xyaw ua ke tsis raug lossis kev ua haujlwm tsis txaus ntawm cov hmoov txhuv nplej siab tuaj yeem ua rau cov hmoov txhuv tsis muaj zog thiab, yog li ntawd, cov ntsiav tshuaj "mos" uas yooj yim tawg thiab tawg. Ntawm qhov tod tes, qhov kev sib xyaw ua ke siab dhau lossis kev sib xyaw ntau dhau tuaj yeem tsim cov hmoov txhuv uas tuab thiab tawv dhau, uas tuaj yeem ua rau muaj qhov tsis zoo xws li tawg thiab lamination thaum lub sijhawm nias ntsiav tshuaj vim yog cua nkag thiab tsis txaus cov yas deformation.
Cov txheej txheem ua granule ntub yog qhov rhiab heev rau cov yam xws li lub sijhawm ntub massing thiab qhov ceev ntawm impeller, uas tuaj yeem ua rau muaj granulation ntau dhau thiab ua rau cov granule ntom ntau ntxiv. Qhov no yog qhov kev sib tw tseem ceeb heev.
Ib qho kev soj ntsuam tseem ceeb yog qhov sib raug zoo tsis sib xws ntawm lub zog ntawm cov granule thiab lub zog tensile ntawm cov ntsiav tshuaj. Feem ntau cov neeg xav tias cov granules muaj zog dua, ntom dua - piv txwv li, los ntawm kev ua granulation siab - yuav tsum ua rau cov ntsiav tshuaj muaj zog dua. Txawm li cas los xij, cov pov thawj qhia tias cov granules tsim los ntawm kev ua granulation siab, thaum yog qhov ntom tshaj plaws thiab muaj zog tshaj plaws, ua rau cov ntsiav tshuaj muaj lub zog tensile qis tshaj plaws. Qhov no tsis yog qhov tsis sib haum yooj yim. Nws qhia tias thaum kev sib txuas ntawm cov granule yuav muaj zog, cov kev sib txuas ntawm cov granule uas tsim thaum lub sijhawm nias ntsiav tshuaj tsis muaj zog. Qhov no yog vim tias cov granules ntom ntom yog cov yas tsawg dua thiab deform tsawg dua thaum nias. Qhov kev deformation txo qis no txo qhov chaw sib cuag ntawm cov granules thiab txwv tsis pub muaj cov choj khov kho, ua rau cov ntsiav tshuaj kawg tsis muaj zog txawm tias cov granules lawv tus kheej muaj zog. Yog li, kev tswj hwm qhov kawg ntawm cov granulation tsis yog hais txog kev ua kom cov granule muaj zog lossis ntom ntau tshaj plaws, tab sis hais txog kev ua tiav qhov sib npaug zoo tshaj plaws uas ua kom muaj kev ntws zoo thiab kev nias txaus los tsim cov ntsiav tshuaj kawg.
Kev Cuam Tshuam ntawm Cov Hmoov Nplej Concentration rau Cov Yam Ntxim Saib Zoo ntawm Cov Khoom Kawg
Kev Nyuaj Siab thiab Kev Nyuaj Siab
Feem ntau, kev ua kom cov binder concentration ntau ntxiv ua rau cov ntsiav tshuaj muaj zog dua thiab tsis yooj yim friability. Starch muab cov khoom sib txuas nruab nrab piv rau cov polymers hluavtaws xws li PVP, feem ntau ua rau cov ntsiav tshuaj mos dua tab sis muaj cov yam ntxwv zoo dua thaum yaj. Ib txoj kev tshawb fawb txog cov hmoov txhuv nplej siab uas tau ua ntej gelatinized pom tias qhov sib txuas concentration ntawm 3% txog 9% yog qhov zoo tshaj plaws rau kev ua tiav cov khoom siv lub cev.
Kev tawg thiab kev yaj
Muaj kev sib raug zoo meej ntawm qhov sib xyaw ntawm cov hmoov txhuv nplej siab thiab qhov nrawm ntawm cov tshuaj yaj. Thaum qhov sib xyaw ntawm cov hmoov txhuv nplej siab nce ntxiv, cov ntsiav tshuaj yuav tawv dua thiab lawv lub sijhawm yaj nce ntxiv, uas ua rau qeeb qhov kev tso tawm ntawm cov khoom xyaw tshuaj (API).
Qhov cuam tshuam ntawm cov hmoov txhuv nplej siab rau kev yaj no piav qhia tau los ntawm kev tsim ib txheej "leached". Thaum lub ntsiav tshuaj uas muaj hmoov txhuv nplej siab raug rau cov khoom siv yaj, cov hmoov txhuv nplej siab ntawm qhov chaw ntawm lub ntsiav tshuaj yuav o thiab tsim ib txheej viscous, zoo li gel. Cov txheej gel no feem ntau tsis muaj API. Yog li ntawd, API yaj ntawm lub plawv ntsiav tshuaj yuav tsum kis mus rau hauv cov hmoov txhuv nplej siab no kom ncav cuag cov khoom siv yaj. Cov txheej txheem diffusion no yog ib kauj ruam qeeb, txwv tus nqi.
Qhov tuab thiab viscosity ntawm cov txheej leached no yog proportional rau qhov concentration ntawm cov hmoov txhuv nplej siab thiab nws qib ntawm gelatinization. Yog li ntawd, cov khoom sib xws ntawm cov hmoov txhuv nplej siab lossis qhov concentration ncaj qha ua rau muaj cov qauv yaj sib txawv, uas yog ib qho tseem ceeb ntawm qhov zoo (CQA) uas cuam tshuam rau kev siv tshuaj.
Kev Ua Kom Ntom Ntawm Cov Granules Thiab Cov Tshuaj Ntsuas
Cov ntsuas tseem ceeb rau kev ntsuam xyuas qhov zoo ntawm cov granule suav nrog qhov ceev ntawm cov khoom loj, qhov ceev ntawm cov khoom me me uas tau muab nias, thiab qhov ntsuas Compressibility Index (CI). Cov kev tshawb fawb tau qhia tias lub sijhawm ntev dua ntawm kev sib sau ua ke lossis qhov ceev ntawm impeller siab dua ua rau qhov ceev ntawm cov granule ntau dua vim tias lawv sib sau ua ke ntau dua.
Qhov kev ua kom ntom no, thaum txhim kho kev ntws, ua rau qhov Compressibility Index qis dua, txhais tau tias cov granules nyuaj rau compress. Yog li ntawd, cov ntsiav tshuaj kawg yuav tsis muaj zog dua li qhov xav tau lossis xav tau lub zog compression siab dua, uas tuaj yeem ua rau cov khoom siv hnav lossis teeb meem zoo li ntsiav tshuaj tawg. Qhov no tsim ib lub voj voog tawm tswv yim nyuaj uas qhov kev hloov pauv me me, zoo li kev nce me ntsis ntawm cov hmoov txhuv nplej siab, tuaj yeem muaj qhov cuam tshuam loj thiab tsis paub tseeb rau qhov zoo ntawm cov khoom kawg.
| Kev Ntsuas ntawm Cov Hmoov Nplej (% w/w) | Qhov Nyuaj Ntawm Cov Tshuaj Ntsuam (N) | Kev yoo yoo ntawm cov ntsiav tshuaj (%) | Lub Sijhawm Poob Qis |
| 0% | Tsis Muaj Phau Ntawv | Tsis muaj | Tsis muaj |
| 3% | 20 – 30 | <1% | Tsis nyob ntawm lub zog compression |
| 6% | 20 – 30 | <1% | Tsis nyob ntawm lub zog compression |
| 9% | 20 – 30 | <1% | Tsis nyob ntawm lub zog compression |
| 15% | 20 – 30 | <1% | Nce nrog lub zog compression |
Lus Cim: Cov nqi hardness sib txawv raws li cov ntaub ntawv rau lub zog compression tshwj xeeb.
Qhov Tseem Ceeb ntawm Kev Saib Xyuas Lub Sijhawm Tseeb
Cov Kev Txwv ntawm Kev Tswj Xyuas Zoo Ib Txwm Muaj
Cov txheej txheem tswj xyuas zoo ib txwm muaj, xws li kev tshuaj xyuas offline lossis ntawm-line ntawm cov granules qhuav lossis cov ntsiav tshuaj, yog qhov ua tau zoo. Lawv vam khom kev kuaj thiab kev sim uas siv sijhawm ntau, tsis muab cov lus teb tam sim ntawd rau cov txheej txheem uas tab tom ua. Lub sijhawm qeeb no ua rau nws tsis tuaj yeem tiv thaiv kev tsim cov khoom tsis ua raws li cov qauv, ua rau muaj kev pov tseg ntau thiab kev poob nyiaj txiag.
Kev daws teeb meem rau kev soj ntsuam qhov concentration ntawm cov hmoov txhuv nplej siab
Cov ntsuas concentration ultrasonictxiav txim siab qhov concentration lossis density ntawm cov kua los ntawm kev ntsuas qhov ceev uas lub suab nthwv dej hla nws. Qhov ceev ntawm lub suab yog ib qho kev ua haujlwm ncaj qha ntawm cov khoom siv lub cev ntawm cov kua, suav nrog nws qhov concentration thiab kub.
Cov thev naus laus zis no zoo rau cov txheej txheem tshuaj vim nws cov txiaj ntsig:
- Tsis yog kev phais:Lub sensor tsis muaj qhov txav mus los thiab tuaj yeem ntxig rau hauv cov yeeb nkab lossis lub nkoj, muab kev ntsuas tiag tiag yam tsis cuam tshuam cov txheej txheem ntws.
- Tsis muaj kev ntxub ntxaug:Qhov kev ntsuas tsis cuam tshuam los ntawm cov xim, qhov meej, lossis qhov nrawm ntawm cov kua dej, uas yog cov kev txwv ntawm cov txheej txheem kho qhov muag.
- Ncaj qha thiab Mechanistic:Nws ncaj qha ntsuas qhov concentration ntawm cov hmoov txhuv nplej siab, uas yog ib qho tseem ceeb ntawm cov txheej txheem uas muaj feem cuam tshuam nrog qhov zoo ntawm cov khoom kawg.
Txoj Haujlwm Teeb tsa ntawm Online Ultrasonic Concentration Meter
Qhov kev teeb tsa tsom mus rau theem kev npaj thiab ntxiv cov binder, uas tshwm sim tam sim ntawd tom qab sib tov hmoov qhuav tab sis ua ntej ntub massing. Qhov kev tso cai no tso cai rau kev hloov kho qhov concentration thiab viscosity ntawm cov hmoov txhuv nplej siab, daws qhov teeb meem ntawm cov hauv paus chiv keeb hauv cov kua binder nws tus kheej.It's recommended rau installon following positipeb:
Blub nkoj npaj hauv qab: Lub ntsuas ultrasonic tau teeb tsa rau hauv kab ntawm lub raj xa dej lossis lub voj voog rov ua dua ntawm lub thawv npaj cov khoom siv. Qhov chaw no ntes cov hmoov txhuv nplej siab.'s concentration thaum lub sijhawm sib tov lossis homogenization, nrhiav pom qhov tsis sib xws vim yog qhov sib txawv ntawm cov hmoov txhuv nplej siab lossis kev npaj yuam kev.
Cov kua pub rau Granulator: Lub ntsuas ultrasonic tau teeb tsa rau hauv kab ntawm txoj kab pub khoom siv (feem ntau yog cov yeeb nkab uas yooj ywm lossis cov yeeb nkab hlau tsis xeb) nyob rau sab saud ntawm lub tshuab granulator.'qhov chaw ntxiv kua lossis lub qhov txau tshuaj. Qhov no nyob tom qab lub twj tso kua mis tab sis ua ntej lub qhov txau tshuaj lossis lub tes faib tshuaj hauv lub tais granulator.
