Kev ntsuas qhov ceev ntawm cov tshuaj acetonitrile (methyl cyanide) kom raug yog qhov tseem ceeb hauv kev tsim cov tshuaj acetonitrile. Acetonitrile qhov volatility siab thiab kev sib xyaw ua ke nrog dej ua rau kev sib cais nyuaj, xav tau cov ntaub ntawv txuas ntxiv mus rau kev rov qab tau cov tshuaj kom raug thiab kev ua kom zoo dua qub.
Kev ntsuas cov tshuaj lom neeg hauv kab txo cov pawg tsis raws li qhov tau teev tseg thiab cov khoom poob hauv cov chaw tsim khoom tas mus li. Kev ntsuas lub sijhawm tiag tiag yog qhov tseem ceeb rau kev lees paub zoo ntawm API, kev rov qab tau cov kuab tshuaj zoo, thiab txo cov kev cuam tshuam rau ib puag ncig los ntawm kev tswj cov khoom neonicotinoids.
Cov Neonicotinoids Yog Dab Tsi
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Cov Txheej Txheemof AcetonitrileKev tsim khoom
Kev tsim cov acetonitrile (methyl cyanide) hauv kev lag luam vam khom peb txoj hauv kev tseem ceeb: kev sib xyaw ua ke, kev hloov pauv nucleophilic, thiab kev sib pauv ester. Txoj hauv kev tseem ceeb yog cov khoom lag luam ntawm kev tsim khoom acrylonitrile, uas xav tau kev sib cais ua ntu zus. Kev sib xyaw ua ke ncaj qha ntawm acetaldehyde nrog ammonia thiab huab cua hla bismuth molybdate tsim cov acetonitrile, tab sis suav rau qhov sib koom me me vim tias cov txiaj ntsig qis dua.
Kev hloov pauv nucleophilic siv haloethanes thiab cyanides, muab CH₃CH₂CN, tab sis tsis tshua muaj ntau vim muaj kev phom sij ntawm cov khoom noj thiab kev siv nyiaj tsawg dua. Kev pauv pauv ester, xws li methanolysis ntawm acetamide, muaj cov txiaj ntsig qis hauv kev lag luam. Acetonitrile lub ntsiab lus kub (81.6 ° C) thiab kev sib xyaw tag nrho nrog dej sib cais - kev ntsuas qhov ceev hauv kab ua kom zoo dua cov theem rov ua dua tshiab thiab kev ntxuav.
Acetonitrile raug suav hais tias yog cov kuab tshuaj polar aprotic hauv cov organic intermediate thiab API synthesis, nrog rau lub luag haujlwm tseem ceeb hauv kev tsim cov tshuaj tua kab neonicotinoid. Kev tswj cov kuab tshuaj kom raug ua rau muaj kev ntshiab, kev tsim khoom, thiab kev nyab xeeb hauv kev rov ua dua thiab kev ua tiav downstream.
Kev Saib Xyuas Qhov CeevCov Kev Sib Twnyob rau hauvAcetonitrileKev tsim khoom
Cov txheej txheem kinetics sai hauv kev tsim acetonitrile xav tau kev saib xyuas lub sijhawm tiag tiag los tswj cov kev teb sai thiab cov khoom nruab nrab ib ntus. Cov txheej txheem ua kom cov kua dej sib xyaw, xws li cov hauv txoj kev ammoxidation, xav tau cov lus teb tam sim ntawd vim yog qhov kub thiab txias rhiab heev. Cov khoom noj hloov pauv los ntawm cov khoom siv rov ua dua tshiab thiab cov khoom siv fossil ua rau muaj kev hloov pauv hauv methyl cyanide concentration, cuam tshuam rau cov kauj ruam downstream. Kev ntsuas qhov ceev inline ntes tau cov kev hloov pauv no tam sim ntawd, tswj cov hom phiaj txawm tias muaj bioethanol lossis ammonia impurities.
Kev tswj cov kuab tshuaj kom raug yog qhov tseem ceeb heev rau cov kauj ruam recrystallization kom huv si, vim tias acetonitrile qhov sib xyaw tag nrho nrog dej yooj yim cuam tshuam kev sib cais los ntawm 5-10%. Kev siv acetonitrile kom raug ua cov kuab tshuaj aprotic polar yog qhov tseem ceeb rau kev tsim cov tshuaj tua kab neonicotinoid, qhov twg qhov sib txawv 0.5% hauv kev sib xyaw ua ke tuaj yeem txo cov khoom tsim tawm los ntawm txog li 3%. Kev ntsuas inline tiv thaiv cov pawg tsis raws li qhov xav tau hauv cov txheej txheem ntws tas mus li, txiav cov khib nyiab kuab tshuaj los ntawm txog li 8% thiab txo cov xwm txheej rov ua dua tshiab.
Cov qauv tshuaj lom neeg ntawm cov tshuaj tua kab neonicotinoids feem ntau
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Cov Txheej Txheem Ntsuas Qhov Ceev Hauv Kab
Cov ntsuas qhov ceev hauv kab xws li lub raj vibrating thiab Coriolis-based sensors xa cov ntaub ntawv tas mus li, lub sijhawm tiag tiag ntawm acetonitrile concentration thaum lub sijhawm ua cov organic synthesis. Cov ntsuas qhov ceev tshuaj los ntawm Lonnmeter muaj feem cuam tshuam ncaj qha nrog cov khoom siv lub cev ntawm acetonitrile, txhawb kev ua haujlwm tsis siv neeg yam tsis tas yuav kuaj tes. Cov inline sensors no ua haujlwm nyob rau hauv cov xwm txheej kub thiab ntws hnyav uas feem ntau tshwm sim hauv cov tshuaj tiv thaiv condensation thiab cov txheej txheem hloov pauv nucleophilic.
Cov ntsuas qhov ceev ntawm lub raj xa dej ntsuas nruab nrab, muab qhov tseeb ± 0.001 g / cm³ txawm tias muaj cov tshuaj volatile xws li acetonitrile. Cov cuab yeej Coriolis muab ob qhov ceev thiab cov lus teb ntws. Ob leeg tuaj yeem tiv taus qhov kub thiab txias feem ntau ntawm -20 ° C txog 120 ° C thiab cov siab ntawm cov kav dej txog li 3 Mpa. Cov khoom siv no tswj hwm kev ua haujlwm zoo thaum tswj cov acetonitrile qhov volatility siab thiab kev sib xyaw ua ke nrog dej.
Kev ntsuas inline tas li ua rau qhov sib piv pub noj zoo dua hauv kev hloov pauv nucleophilic, kaw cov voj voog rov qab hauv kev pauv ester, thiab txo qhov poob ntawm cov khoom tawm ntawm cov pawg tsis raws li qhov tau teev tseg. Kev saib xyuas inline kuj ua rau muaj kev tsim khoom API zoo thiab txhawb nqa cov kev cai huv huv hauv kev tshuaj thiab kev tsim cov tshuaj neonicotinoid.
Cov txiaj ntsig ntawm kev sib koom ua ke ntawm Inline Density/Concentration Meters
Cov ntsuas qhov ceev hauv kab ua rau pom tau tam sim ntawd ntawm cov txheej txheem hloov pauv hauv kev tsim cov acetonitrile, txhawb nqa kev ua kom huv si tas mus li thiab txo cov kev hloov kho qeeb. Kev ntsuas inline tiag tiag ua kom muaj cov khoom acetonitrile raug rau cov tshuaj tiv thaiv condensation thiab nucleophilic substitution. Kev tswj hwm qhov concentration tas li tiv thaiv cov khoom tsis raws li qhov xav tau thaum lub sijhawm tsim cov methyl cyanide, txiav cov khoom poob txog li 15% piv rau kev kuaj offline.
Cov cuab yeej Lonnmeter inline sib xyaw nrog cov txheej txheem nyuaj, tswj cov zis txhim khu kev qha thaum lub sijhawm hloov pauv ester sai lossis cov txheej txheem nplua nuj. Kev saib xyuas zoo dua thaum lub sijhawm recrystallization tiv thaiv cov khoom kom huv, tso cai rau cov organic synthesis kom ncav cuag cov txiaj ntsig siab dua 98%. Cov ntaub ntawv ntws raug qhia txog kev tswj hwm cov kuab tshuaj zoo, txo qis kev pheej hmoo ntawm kev ua qias tuaj hauv kev tsim cov khoom xyaw tshuaj (API).
Hauv kev tsim cov tshuaj tua kab neonicotinoids, cov theem acetonitrile ruaj khov ua rau qhov ua tau zoo ntawm cov tshuaj tiv thaiv thiab tiv thaiv cov khoom tsis xav tau. Kev ntsuas inline txo qhov kev puas tsuaj ib puag ncig uas cuam tshuam nrog kev tsim cov tshuaj neonicotinoid los ntawm kev muab kev taug qab cov kuab tshuaj kom meej, pab txhawb kev ua raws li txoj cai thiab kev siv zog ua kom ruaj khov.
Daws Cov Teeb Meem Inline Density in AcetonitrilePkev tsim khoom
Thov kom muaj tus nqi uas haum rau koj los daws cov teeb meem ntawm kev ntsuas qhov ntom ntom hauv kab thiab txhawb kev tswj hwm hauv kev tsim cov acetonitrile, suav nrog cov khoom thiab kev siv cov methyl cyanide, cov ntawv thov polar aprotic solvent, thiab cov kev cai ib puag ncig rau cov txheej txheem neonicotinoid.
Lub sijhawm tshaj tawm: Lub Ib Hlis-27-2026
